toremifene


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toremifene

 [tor´ĕ-mĭ-fēn″]
an analogue of tamoxifen that acts as an estrogen antagonist; used as the citrate salt in palliative treatment of metastatic breast carcinoma, administered orally.

toremifene

/to·re·mi·fene/ (tor´ĕ-mĭ-fēn″) an analogue of tamoxifen that acts as an estrogen antagonist; used as the citrate salt in the palliative treatment of metastatic breast carcinoma.

toremifene

an antineoplastic.
indications It is used to treat advanced breast carcinoma that is not responsive to other therapy in estrogen-receptor-positive patients (usually postmenopausal).
contraindications Known hypersensitivity to this drug and pregnancy prohibit its use.
adverse effects Life-threatening effects are thrombocytopenia and leukopenia. Other adverse effects include altered taste (anorexia), vaginal bleeding, pruritus vulvae, rash, alopecia, chest pain, depression, hypercalcemia, ocular lesions, retinopathy, corneal opacity, and blurred vision (high doses). Common side effects include nausea, vomiting, hot flashes, headache, and light-headedness.

toremifene

Oncology An antiestrogen that may control certain CAs, ↓ recurrence. Cf Tamoxifen.

toremifene

An anti-oestrogen drug used to treat oestrogen-dependent breast cancers that have spread. Most breast cancers are oestrogen-dependent. A brand name is Fareston.
References in periodicals archive ?
Multiple clinical trials have investigated the use of a variety of pharmacologic agents and nonpharmacologic supplements, such as 5-[alpha] reductase inhibitors, 3,3'-diindolylmethane, selenium, soy compounds, toremifene citrate, green tea catechins, and lycopenes, among others, but none of these agents has emerged as particularly promising for effective chemoprevention of prostate cancer (as reviewed in DeMarzo et al (3)), although some trials are still ongoing to date.
Compartmentalized uterotrophic effects of tamoxifen, toremifene, and estradiol in the ovariectomized Wistar (Han) rat.
In a new research, scientists said the painkiller ibuprofen and the chemotherapy drug toremifene can "disable" the Ebola virus.
Effect of combined therapy with the antiestrogen agent toremifene and local hyperthermia on breast cancer cells implanted in nude mice.
Glucose-6-phosphate (G6P), glucose-6-phosphate dehydrogenase (G6PDH), and pnicotinamide adenine dinucleotide phosphate (NADP+), tamoxifen (TAM), 4'-hydroxytamoxifen (HTAM), toremifene (TOR), 4'-hydroxytoremifene (HTOR), and mebendazole (MBZ, internal standard, IS) were obtained from Sigma-Aldrich (St.
Comparing the effects of atamestane, toremifene and tamoxifen alone and in combination, on bone, serum lipids and uterus in ovariectomized rats.
002 ([section]) Virus variant Toremifene or subtype [EC.
I generation: Tripbenylethylene derivative- Tamoxifene, Droloxifene, Toremifene.
Interferons could also be possible candidates, Friede said, adding that the experts had also discussed breast cancer drug toremifene, but found significant "safety concerns.
Toremifene to reduce fracture risk in men receiving androgen deprivation therapy for prostate cancer.
Relevance of the selective oestrogen receptor modulators tamoxifen, toremifene and domiphene in doping field: endogenous steroids urinary profile after multiple oral doses.
The findings open the way for further testing of the drugs, clomiphene and toremifene, against the deadly virus.