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toremifene/to·re·mi·fene/ (tor´ĕ-mĭ-fēn″) an analogue of tamoxifen that acts as an estrogen antagonist; used as the citrate salt in the palliative treatment of metastatic breast carcinoma.
indications It is used to treat advanced breast carcinoma that is not responsive to other therapy in estrogen-receptor-positive patients (usually postmenopausal).
contraindications Known hypersensitivity to this drug and pregnancy prohibit its use.
adverse effects Life-threatening effects are thrombocytopenia and leukopenia. Other adverse effects include altered taste (anorexia), vaginal bleeding, pruritus vulvae, rash, alopecia, chest pain, depression, hypercalcemia, ocular lesions, retinopathy, corneal opacity, and blurred vision (high doses). Common side effects include nausea, vomiting, hot flashes, headache, and light-headedness.