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topotecanA water-soluble derivative of camptothecin, obtained from the Chinese tree Camptotheca accuminata. It is a topoisomerase inhibitor which is FDA-approved for treating ovarian, cervical and small cell carcinoma of the lung.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
topotecanHycamtin® Oncology A topoisomerase I inhibitor used for refractory ovarian CA, small cell CA, and for colorectal and breast CAs Adverse effects Dose-limiting–never if baseline neutrophils are < 1500 cells/mm3–neutropenia, anemia, thrombocytopenia; N&V, diarrhea, alopecia Contraindications Pregnancy, breastfeeding, prior BM depression. See Topoisomerase I.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
topotecanThe first of the CAMPOTHECIN analogue drugs to be approved for clinical use. Topotecan is a TOPOISOMERASE inhibitor drug used to treat cancer of the ovary and small cell cancer of the lung. (see CYTOTOXIC DRUGS). A brand name is Hycamtin.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005