topotecan


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topotecan

A water-soluble derivative of camptothecin, obtained from the Chinese tree Camptotheca accuminata. It is a topoisomerase inhibitor which is FDA-approved for treating ovarian, cervical and small cell carcinoma of the lung.

topotecan

Hycamtin® Oncology A topoisomerase I inhibitor used for refractory ovarian CA, small cell CA, and for colorectal and breast CAs Adverse effects Dose-limiting–never if baseline neutrophils are < 1500 cells/mm3–neutropenia, anemia, thrombocytopenia; N&V, diarrhea, alopecia Contraindications Pregnancy, breastfeeding, prior BM depression. See Topoisomerase I.

topotecan

The first of the CAMPOTHECIN analogue drugs to be approved for clinical use. Topotecan is a TOPOISOMERASE inhibitor drug used to treat cancer of the ovary and small cell cancer of the lung. (see CYTOTOXIC DRUGS). A brand name is Hycamtin.
References in periodicals archive ?
Doctors have prescribed a two-month course of Topotecan, which is still being tested in the UK and is used by sufferers who do not respond to more conventional treatments.
Meanwhile, Jade will start a two-month course of the new wonder drug Topotecan, normally administered alongside a course of chemotherapy - a gruelling treatment that has already left Jade's body sick and weak.
She is also being given a new drug Topotecan, which is still being tested in the UK.
She will begin a two-month course of Topotecan next week, which it is hoped will shrink the deadly tumours.
During the time period of April 14-18, 1999, intravenous topotecan was administered to Maura daily for a total of 5 doses, which she received as an outpatient.
Examples of topoisomerase I inhibitors are ironotecan and topotecan. Topoisomerase II inhibitors are Amsacrine and Etoposide.
Various drugs which has been used as a radio sensitizer for concurrent chemo radiation include hydroxyurea (4), mitomycin-C (5) 5-fluorouracil, Irinotecon, Topotecan, and Paclitaxel in combination with cisplatin (6-9).
Researchers reported at the SGO meeting that adding thalidomide to the chemotherapy drug topotecan improved disease-free survival in recurrent ovarian cancer (as well as in primary peritoneal or fallopian tube cancers).
Topotecan (Hycamtin): This drug is used to treat metastatic (cancer that has spread) ovarian cancer after initial or subsequent chemotherapy has failed.
A recent clinical trial, conducted by the Gynecologic Oncology Group, has demonstrated that the combination of cisplatin and topotecan is the current standard combination for the management of metastatic disease requiring chemotherapy.