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topotecan/to·po·te·can/ (to″po-te´kan) an antineoplastic that inhibits DNA topoismerase; used as the hydrochloride salt in the treatment of metastatic ovarian carcinoma and small cell lung carcinoma.
an antineoplastic hormone.
indication It is used to treat metastatic carcinoma of the ovary after failure of traditional chemotherapy.
contraindications Factors that prohibit the use of this drug are known hypersensitivity, lactation, and severe bone marrow depression.
adverse effects Life-threatening effects are neutropenia, leukopenia, thrombocytopenia, anemia, and sepsis. Other adverse effects are abdominal pain, constipation, diarrhea, obstruction, nausea, stomatitis, vomiting, increased alanine aminotransferase and aspartate aminotransferase, anorexia, arthralgia, asthenia, headache, myalgia, pain, dyspnea, and total alopecia.