The remaining one strain, which possessed an amino acid alteration in the GrlB subunit of topoisomerase
IV, had increased susceptibility to galangin.
DNA polymerase and topoisomerase
are the important reported targets for cancer chemotherapy.
and their poisoning by anticancer and antibacterial drugs.
The critical involvement of DNA topoisomerases
in various essential cellular processes has led to the development of topoisomerase
poisons for use as antibacterial [192, 193] or anticancer therapeutics [194, 195].
Kasparkova et al., "Inhibition of DNA topoisomerases
I and II and growth inhibition of HL-60 cells by novel acridine-based compounds," European Journal of Pharmaceutical Sciences, vol.
Background: To investigate the role of a topoisomerase
I inhibitor (topotecan) in chemoresistant ovarian cancer-initiating cells.
This study could also explain why some people with mutations in topoisomerases
develop autism and other neurodevelopmental disorders.
"Our study shows the magnitude of what can happen if topoisomerases
are impaired," said senior study author Mark Zylka, PhD, associate professor in the Neuroscience Center and the Department of Cell Biology and Physiology at UNC.
Camptothecine (CPT), a quinoline alkaloid, is a potent inhibitor of eukaryotic topoisomerase
Previous studies (42) have demonstrated that changes in topoisomerases
are insufficient to explain the level of resistance to quinolones in S.
Within human TCGA data, we found that topoisomerases
are differentially expressed across the 4 GBM subtypes, with proneural subtype showing the highest levels of both TOP2a and TOP2b expressions.