topoisomerase inhibitors

topoisomerase inhibitors

a class of antineoplastic agents that interfere with the arrangement of DNA in cells.
References in periodicals archive ?
In partnership with the NIAID, the company Entasis recently completed a phase II study of zoliflodacin, an oral agent in a novel class of topoisomerase inhibitors.
The company's scientists have reportedly found novel bacterial topoisomerase inhibitors that work as antibiotics against drug resistant Gram-negative bacteria.
Topoisomerase inhibitors potentiate the effect of retinoic acid on cell growth inhibition and induction of differentiation of leukemia HL-60 cells.
Topoisomerase inhibitors constitute a class of chemopreventive agents that hamper carcinogenesis via their antiproliferative or cell-differentiating action (Ramirez-Mares et al.
A new high-throughput assay, developed recently in the laboratory of Prof Tony Maxwell of the John Innes Centre (and co-founder of Inspiralis), will also provide a huge advance on the standard gel-based screening method for topoisomerase inhibitors.
In the present study we have tested the AF4 bcr for sensitivity to cleavage by topoisomerase inhibitors.
Many of the antitumour antibiotics can work as topoisomerase inhibitors.
Besides his administrative and teaching activities, DiGate is known for his research on the role of DNA topoisomerases in DNA replication and the design and synthesis of topoisomerase inhibitors.
A new class of cancer drugs -- topoisomerase inhibitors -- is now in use in the United States for treating certain cancers.
Topoisomerase inhibitors comprise a major and established class of cytotoxic anti-cancer agent that is widely used to treat cancer patients.
The key classes of mechanism of action include vascular endothelial growth factor (VGEF) inhibitors, tubulin inhibitors, topoisomerase inhibitors, mammalian target of rapamycin (mTOR) inhibitors and DNA synthesis inhibitors.