In partnership with the NIAID, the company Entasis recently completed a phase II study of zoliflodacin, an oral agent in a novel class of topoisomerase inhibitors
The company's scientists have reportedly found novel bacterial topoisomerase inhibitors
that work as antibiotics against drug resistant Gram-negative bacteria.
potentiate the effect of retinoic acid on cell growth inhibition and induction of differentiation of leukemia HL-60 cells.
constitute a class of chemopreventive agents that hamper carcinogenesis via their antiproliferative or cell-differentiating action (Ramirez-Mares et al.
A new high-throughput assay, developed recently in the laboratory of Prof Tony Maxwell of the John Innes Centre (and co-founder of Inspiralis), will also provide a huge advance on the standard gel-based screening method for topoisomerase inhibitors
In the present study we have tested the AF4 bcr for sensitivity to cleavage by topoisomerase inhibitors
Many of the antitumour antibiotics can work as topoisomerase inhibitors
Besides his administrative and teaching activities, DiGate is known for his research on the role of DNA topoisomerases in DNA replication and the design and synthesis of topoisomerase inhibitors
A new class of cancer drugs -- topoisomerase inhibitors
-- is now in use in the United States for treating certain cancers.
comprise a major and established class of cytotoxic anti-cancer agent that is widely used to treat cancer patients.
The key classes of mechanism of action include vascular endothelial growth factor (VGEF) inhibitors, tubulin inhibitors, topoisomerase inhibitors
, mammalian target of rapamycin (mTOR) inhibitors and DNA synthesis inhibitors.
Complex response of breast epithelial cell lines to topoisomerase inhibitors