Evidence also suggests that the generation of ROS and the induction of topoisomerase
Il-DNA complexes may play a role in curcumin-induced cancer cell death (Kuo et al.
Washington, August 29 ( ANI ): Researchers have claimed that problems with a key group of enzymes called topoisomerases
could have profound effects on the genetic machinery behind development of brain and potentially lead to autism spectrum disorder (ASD).
Camptothecins with their docking score of their antineoplatic, topoisomerase
I inhibitory, DNA intercatalor activity are shown in Tables 1,2 and 3.
In cancer, cells rapidly divide in an uncontrolled manner and topoisomerase
inhibitors can block this uncontrolled cell division.
The finding that PARP inhibitors improve the anti-cancer activity of Topoisomerase
1 poisons indicates they may be useful in the treatment of bowel cancer.
The finding that they improve the anti-cancer activity of topoisomerase
1 poisons indicates they may be useful in treatment of bowel cancer.
The case of topoisomerase
inhibitors is unusual in that these drugs have gone through the entire approval process for cancer.
Calf thymus topoisomerase
I was purchased from Life Technologies (Gaithersburg, Md).
Experiments have centred on a protein called topoisomerase
II, which is attacked by the anti-cancer drug etoposide, regularly used to treat leukaemia.
X-ray crystallography has now revealed the atomic structure of a critical part of one of the relaxing callers, topoisomerase
I, from the bacterium Escherichia coli.
This newly opened, randomized trial is designed to compare the efficacy of CRLX101, a nanopharmaceutical that inhibits both topoisomerase
1 and hypoxia-inducible factor-1 alpha (HIF-1), to topotecan as second-line therapy for relapsed SCLC.
According to the investigators, as many as one-third of patients with GIST may benefit from anthracyclines and topoisomerase
inhibitors, based on the expression patterns of topoisomerases
1 (TOPO1, 34%) and 2A (TOPO2A, 32%).