tophus


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Related to tophus: hyperuricemia, gout

tophus

 [to´fus] (L.)
1. a chalky deposit of sodium urate occurring in gout; tophi form most often around the joints in cartilage, bone, bursae, and subcutaneous tissue and in the external ear, producing a chronic, foreign-body inflammatory response.
2. dental calculus.
Tophus. Typical appearance of tophi, which are common in chronic gout, shown on an index finger. From Ignatavicius and Workman, 2000.
tophus syphili´ticus syphilitic node.

to·phus

, pl.

to·phi

(tō'fŭs, tō'fī),
1.
2. A salivary calculus, or tartar.
Synonym(s): gouty pearl
[L. a calcareous deposit from springs, tufa]

tophus

/to·phus/ (to´fus) pl. to´phi   [L.] a deposit of sodium urate in the tissues about the joints in gout, producing a chronic, foreign-body inflammatory response.

tophus

(tō′fəs)
n. pl. to·phi (-fī)
1. A deposit of urates in the skin and tissue around a joint or in the external ear, occurring in gout. Also called chalkstone.
2. A concretion of mineral salts and organic matter deposited on the surface of the teeth.

tophus

[tō′fəs] pl. tophi
Etymology: L, tufa, porous rock
a calculus containing sodium urate that develops in fibrous tissue around joints, typically in patients with gout. -tophaceous, adj.
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Tophus

tophus

The pathognomonic lesion of gout, which appears grossly when preserved in alcohol or other non-aqueous solution as a nodular mass of white chalky, pasty material composed of crystalline and amorphous urates–eg, monosodium urate monohydrates, surrounded by mononuclear cells, fibroblasts and a foreign body-type giant cell reaction with epithelioid histiocytes. See Gouty toe.

to·phus

, pl. tophi (tō'fŭs, -fī)
1. See: gouty tophus
2. A salivary calculus, or tartar.
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TOPHI: Left and right hands of a patient with multiple deforming gouty tophi
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TOPHI: Left and right hands of a patient with multiple deforming gouty tophi

tophus

(to'fus) plural.tophi [L., porous stone]
A deposit of sodium biurate in tissues near a joint, in the ear, or elsewhere in individuals with gout.
Synonym: gouty pearl See: illustration

Tophus (plural, tophi)

A chalky deposit of a uric acid compound found in gout. Tophi occur most frequently around joints and in the external ear.
Mentioned in: Gout

gouty tophus

localized deposition of crystalline monosodium urate monohydrate in peripheral tissues (e.g. first metatarsophalangeal joint); subungual tophus formation causes nail dystrophy, with onychauxis and/or onycholysis

to·phus

, pl. tophi (tō'fŭs, -fī)
A salivary calculus or tartar.

tophus

pl. tophi [L.]
1. a chalky deposit of sodium urate occurring in gout; tophi form most often around the joints in cartilage, bone, bursae and subcutaneous tissue.
2. dental calculus.
References in periodicals archive ?
For patients with RCG, tophus burden is a serious factor in the condition's impact on long-term functionality.
Adenuric([R])(febuxostat) 80 mg and 120 mg tablets are indicated for the treatment of chronic hyperuricaemia for conditions in which urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).
88 mg/dL; 7) erythrocyte sedimentation rate greater than 20 mm/h for men or greater than 30 mm/h for women; and 8) presence of tophus.
02) of patients with tophi treated with KRYSTEXXA every 2 weeks achieved a complete response, defined as 100% resolution of at least one target tophus, no new tophus appearing and no single tophus showing progression, compared to 8% of patients receiving placebo.
2, inset on right with magnified cytology smear), consistent with a gouty tophus.
Adenuric([R])is to be indicated for the treatment of chronic hyperuricaemia for conditions in which urate deposition has already occurred (including a history, or presence of, tophus and/or gouty arthritis).
GlaxoSmithKline's Zyloprim/Zyloric, provide considerable commercial opportunity for emerging antigout therapies that offer a faster rate of tophus resolution," stated Decision Resources Analyst Christine Helliwell, Ph.
On positron emission tomography (PET) with 18-fluoro-2-deoxy-D-glucose, a gouty tophus may demonstrate moderately increased uptake but less than that expected of a malignancy.
The current proof-of-concept study, in addition to assessing the accuracy of DECT in gout patients, also measured the uric acid burden in peripheral joints and performed a computerized quantification of tophus volume.
005) for the elimination of gout tophi (complete elimination of at least one tophus and no new tophi), whereas the every four week dose group did not attain statistical significance.
Eastern Time -- First Application of Computer-Assisted Analysis of Digital Photographs for Assessing Tophus Response: Phase 3 Studies of Pegloticase in Treatment Failure Gout (Abstract # 1111) - October 19, 2009 at 9:00 a.
Nearly two-thirds of the 26 study patients who had palpable tophi at baseline had no detectable tophus after 4 years, in the longest trial involving the novel nonpurine selective xanthine oxidase inhibitor, he reported.