tophus


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Related to tophus: hyperuricemia, gout

tophus

 [to´fus] (L.)
1. a chalky deposit of sodium urate occurring in gout; tophi form most often around the joints in cartilage, bone, bursae, and subcutaneous tissue and in the external ear, producing a chronic, foreign-body inflammatory response.
2. dental calculus.
Tophus. Typical appearance of tophi, which are common in chronic gout, shown on an index finger. From Ignatavicius and Workman, 2000.
tophus syphili´ticus syphilitic node.

to·phus

, pl.

to·phi

(tō'fŭs, tō'fī),
1.
2. A salivary calculus, or tartar.
Synonym(s): gouty pearl
[L. a calcareous deposit from springs, tufa]

tophus

(tō′fəs)
n. pl. to·phi (-fī)
1. A deposit of urates in the skin and tissue around a joint or in the external ear, occurring in gout. Also called chalkstone.
2. A concretion of mineral salts and organic matter deposited on the surface of the teeth.

tophus

The pathognomonic lesion of gout, which appears grossly when preserved in alcohol or other non-aqueous solution as a nodular mass of white chalky, pasty material composed of crystalline and amorphous urates–eg, monosodium urate monohydrates, surrounded by mononuclear cells, fibroblasts and a foreign body-type giant cell reaction with epithelioid histiocytes. See Gouty toe.

to·phus

, pl. tophi (tō'fŭs, -fī)
1. See: gouty tophus
2. A salivary calculus, or tartar.
Enlarge picture
TOPHI: Left and right hands of a patient with multiple deforming gouty tophi
Enlarge picture
TOPHI: Left and right hands of a patient with multiple deforming gouty tophi

tophus

(to'fus) plural.tophi [L., porous stone]
A deposit of sodium biurate in tissues near a joint, in the ear, or elsewhere in individuals with gout.
Synonym: gouty pearl See: illustration

Tophus (plural, tophi)

A chalky deposit of a uric acid compound found in gout. Tophi occur most frequently around joints and in the external ear.
Mentioned in: Gout

to·phus

, pl. tophi (tō'fŭs, -fī)
A salivary calculus or tartar.
References in periodicals archive ?
Malignant fibrous histiocytoma arising in a gouty tophus at the second metacarpophalangeal joint.
Hemilaterally symptomatic bipartite patella associated with bone erosions arising from a gouty tophus: A case report.
Only two reports were found in the literature describing symptoms due to a single gouty tophus. Law and coworkers (5) presented a patient who complained of anterior knee pain and limited ROM from 10[degrees] to 100[degrees] of flexion, who was found to have a single tophus in the patellofemoral compartment.
With the advent of the disease, a tophus may cause persistent pain that impairs foot function, superimposed infection and uncontrolled drainage, or enlargement of a digit.
Orienting Joseph's left foot directly toward the viewer, as Martini has done, gives the tophus the greatest degree of visual emphasis.
The serum urate level should be lowered to 6 mg/dl for the prevention of attacks and tophus regression, and xanthine oxidase inhibitor allopurinol is used for this purpose.
"Dr Pascual's findings are exciting and have further opened a door into an area of tophus development that until now has been somewhat elusive.
He underwent excision of the olecranon bursae and biopsy from the tophus involving first toe three years ago.
Patients also had to have at least one measurable tophus on the hands/wrists and/or feet/ ankles at least 5 mm in width and up to 20 mm in length.
The presence of monosodium urate monohydrate crystals in a symptomatic joint, bursa, or tophus is sufficient to diagnose gout, according to new gout classification criteria from the American College of Rheumatology and the European League Against Rheumatism.
The crystals then promote further degradation of the cartilage matrix through tophus formation and inflammation.