tophi


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to·phi

(tō'fī),
Plural of tophus.

to·phi

(tō'fī)
Plural of tophus.
Enlarge picture
TOPHI: Left and right hands of a patient with multiple deforming gouty tophi
Enlarge picture
TOPHI: Left and right hands of a patient with multiple deforming gouty tophi

tophus

(to'fus) plural.tophi [L., porous stone]
A deposit of sodium biurate in tissues near a joint, in the ear, or elsewhere in individuals with gout.
Synonym: gouty pearl See: illustration

tophi

Crystals of monosodium urate that may appear as chalky outcroppings on the skin of the ear, or may occur in tendons or joints in GOUT.

Tophus (plural, tophi)

A chalky deposit of a uric acid compound found in gout. Tophi occur most frequently around joints and in the external ear.
Mentioned in: Gout
References in periodicals archive ?
The period for the formation of tophi following the first episode of the acute gout arthritis is estimated at an average of 11.6 years (6).
Up to the last follow-up visit in September 2017, his tophi were smaller as assessed by physical examination and DECT [Figure 1]f and no renal calculi was found.
A lower sUA target (<5 mg/dL) to facilitate faster dissolution of crystals is recommended for patients with severe gout (tophi, chronic arthropathy, frequent attacks) until total crystal dissolution and resolution of gout are achieved.
Zhang, "Widespread gouty tophi on 18F-FDG PET/CT imaging," Clinical Nuclear Medicine, vol.
"Since the trial was 12 months long, the time over which serum urate was less than 6 mg/dL was not long enough to demonstrate the benefits on flares and tophi," she said.
Tophi were present in bilateral second metacarpals and the left elbow.
Carpal tunnel syndrome caused by gouty tophi is not rare, its incident reported to be approximately 0.6%.
These are deposited into joints and various tissues, forming tophi. The microtophi are sealed off by proteins, and consequently do not cause an inflammatory response.
Treatment is lifelong, but maintaining urate levels at <6 mg/dL will result in tophi resolution over time and a reduction in acute attacks of gout.
There was no history of arthritis, increased uric acid, and tophi that would indicate crystal arthropathy.
In patients with a long evolution of hyperuricemia and many acute attacks, gout can also be found in a chronic form, having as a main manifestation the gouty tophi (tophus = a friable and porous stone), a tophus being a deposit of small monosodium urate crystals surrounded by inflammatory cells.
Initial acute attacks of synovitis may, without adequate treatment, become chronic with the formation of tophi (crystalline deposits) within the joint and associated bony destruction.