tophaceous gout


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Related to tophaceous gout: colchicine

to·pha·ceous gout

gout in which deposits of uric acid and urates occur as gouty tophi adjacent to the affected joint.

tophaceous gout

Etymology: L, tufa, porous rock
a form of purine metabolism disorder characterized by formation of chalky deposits of sodium biurate under the skin and in the joints. If untreated, the deposits may eventually destroy the involved joints.

to·pha·ceous gout

(tō-fā'shŭs gowt)
The condition in which deposits of uric acid and urates occur as gouty tophi.

tophaceous gout

Gout marked by the development of tophi (deposits of sodium urate) in the joints and in the external ear.
See also: gout
References in periodicals archive ?
The case described in the present report is an unusual presentation of tophaceous gout with a single tophus in the intercondylar notch resulting in isolated extension loss.
Today's approval is reportedly the first approved therapy in the EU to address a significant unmet medical need for patients with chronic tophaceous gout.
Tophaceous gout is a rare clinical manifestation that has been observed in patients with chronic gout; diffuse involvement of the knees, as in our case, is even rarer.
It becomes clear that this patient is at high risk for septic arthritis because of his history of tophaceous gout.
In conclusion; (i) although rare, radiographic findings of destructive bone and joint changes simulating cancer (primary or metastasis) may be seen in tophaceous gout that may require histopathologic examination for the correct diagnosis; (ii) delayed surgical treatment may result in amputation of the digits.
Gout has two clinical presentations affecting the musculoskeletal system--acute arthritis and chronic tophaceous gout.
Tophaceous gout is an uncommon condition with tophi being reported commonly at the great toe, feet, hand joints and olecranon.
After years of acute intermittent disease, about 10% of patients develop tophaceous gout.
Caption: 'When I see patients with tophaceous gout, my target is never 6 [mg/dl].
The agency has issued a positive opinion recommending approval of a marketing authorisation in the European Union for KRYSTEXXA for the treatment of severe debilitating chronic tophaceous gout in adult patients who may also have erosive joint involvement and who have failed to normalise serum uric acid with xanthine oxidase inhibitors at the maximum medically appropriate dose, or for whom these medicines are contraindicated.
For patients with severe cases of tophaceous gout or those who can't tolerate the other medications, the drug pegloticase (Krystexxa), given as an infusion, may be an option.