deposits in knee joints and other areas have occasionally been reported, but detailed clinical information is lacking.
There are also tophaceous
pseudogout and tumoral CPPD, which are solitary space-occupying lesions, often seen in the digits (Figure 5).
deposits may mimic space-occupying lesions and occasionally be confused with rheumatoid nodules.
Caption: 'When I see patients with tophaceous
gout, my target is never 6 [mg/dl].
Coexistence of chronic tophaceous
gout and rheumatoid arthritis.
The exclusive license enables Selecta to develop pegsiticase in patients with refractory and tophaceous
gout and apply its immunomodulatory Synthetic Vaccine Particle (SVP) platform to optimize the safety and efficacy profile for patients at risk of immunogenicity.
It usually begins as self-limited attacks of acute inflammatory arthritis, but the long-standing hyperuricemia causes erosive polyarthritis and chronic tophaceous
forms of the disease in some patients.
Dual energy computed tomography in tophaceous
Medically reversible quadriparesis in tophaceous
In gout, tophaceous
deposits are present and the erosions appear as "overhanging edges," neither of which is seen in EOA.
KRYSTEXXA was approved by the EMA in January 2013 to treat severe, debilitating chronic tophaceous
Gout is defined as the inability to metabolize purine and can present in four different phases: asymptomatic hyperuricemia, recurrent attacks of acute arthritis, intercritical gout, and chronic tophaceous