A 2-year, randomized European trial showed that a top-down approach
, combining early immunosuppression with infliximab (Remicade) and azathioprine (Imuran in Canada, Azasan in the United States) followed by azathioprine monotherapy and, if necessary, additional infliximab and corticosteroids, was more effective than step-up management for induction of remission and reduction of steroids in the short term (Lancet 2008;371:660-7).
The top-down approach
uses business strategy to identify the core competencies of the business and the business processes that are required to support them.
Steve Allkins, group managing director for Chase Midland and main board director with responsibility for health and safety, said: "Chase takes a top-down approach
to health and safety, which has consistently resulted in us surpassing the industry average for accident frequency rates.
We have to ensure that we change the culture of health boards so the secretive, top-down approach
is done away with.
We're not using the top-down approach
, we're using the innovators approach," says Duchesne.
Endorsed by WowWee, Robosapien's manufacturer, this manual opens with the designer's remarks on how this type of robotics represents a grassroots rather than top-down approach
for both PC and Mac users.
As for what leadership approach should be taken by the next LDP president, Abe said, ''It may be difficult for the next prime minister to take a top-down approach
similar to Prime Minister Junichiro Koizumi's.
The first phase of this process takes a top-down approach
to define a strategy.
The top-down approach
begins with an organization's global targets that are then pushed down to the various elements of the company.
And with so much heartbreaking news and murderous drama to cover, you barely noticed his curious top-down approach
, whereby the truth of a country was discovered almost exclusively by interviewing its leading intellectuals, politicians, and businessmen, preferably over a round or three of golf.
The best solutions will use a combination of the strategies--a top-down approach
to develop the higher-level categories in the taxonomy aligned with business strategy, and a bottom-up approach to refine lower-level concepts and enable automatic categorization of content.
They see his top-down approach
as being somewhat oppressive,'' he said.