tonofilament


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ton·o·fil·a·ment

(ton'ō-fil'ă-ment),
A structural cytoplasmic protein, of a class known as intermediate filaments, bundles of which together form a tonofibril; a tonofilament is made up of a variable number of related proteins, keratins, and is found in all epithelial cells, but is particularly well developed in the epidermis.

ton·o·fil·a·ment

(ton'ō-fil'ă-mĕnt)
A structural cytoplasmic protein, bundles of which together form a tonofibril; tonofilaments are made up of a variable number of related proteins, keratins, and are found in all epithelial cells.

tonofilament

(ton″ō-fil′ă-mĕnt) [ tono- + filament]
A bundle of intermediate filaments within a cell. They bind the pieces of the cytoskeleton to each other and to the cell membrane.
References in periodicals archive ?
Pathogenic mutations leading to non-conservative amino acid substitutions cluster at the boundaries of the a-helical rod region.5 The characteristic histological features of BIE hyperkeratosis with lysis and tonofilament clumping in granular layer keratinocytes are termed epidermolytic hyperkeratosis' and in some countries this term is also used to define the clinical picture.2 BIE typically presents with epidermolysis (fragile skin) which gives way to gradual evolution of hyperkeratosis.
(69) Formalinfixed material retrieved from a paraffin block may be satisfactory because microvilli and tonofilament bundles tend to be preserved.
For epithelioid mesotheliomas these include very long, thin apical microvilli that do not have a glycocalyx, as opposed to the generally shorter microvilli of adenocarcinomas that usually do have a glycocalyx; perinuclear tonofilament bundles; the presence of basal lamina; and long desmosomes.
For epithelioid mesotheliomas these include very long thin apical microvilli that do not have a glycocalyx, as opposed to the generally shorter microvilli of adenocarcinomas that usually do have a glycocalyx; perinuclear tonofilament bundles; the presence of basal lamina; and long desmosomes.
Other findings indicating mesothelial lineage of the malignant cells are filaments, which often surround the nucleus, and cytoplasmic, coarse tonofilaments, the latter correlating to the expression of cytokeratin 5 and a finding of squamoid differentiation.
They had relatively few microorganelles and rare tonofilaments, and their cell membrane formed tight junctions or desmosome-like junctions with adjacent cells (Figures 2(a) and 2(b)).
[3] identified what were thought to be tonofilaments embedded in an amorphous matrix indicating that disruption of epidermal or follicular tonofilaments may play a role in the pathogenesis.
The spindle cells contain desmosomes and tonofilaments, supporting their squamous cell origin.
Electron microscopy shows the basaloid component to have desmosomes, rare tonofilaments and loose stellate granules or replicated basal lamina within the cystic spaces.
Apoptotic bodies rich in tonofilaments were not found.
The finding of epithelial elements, mature desmosomes, and tonofilaments in the original neoplasm secured the diagnosis of spindle-cell squamous carcinoma.