tonofibril


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tonofibril

 [ton´o-fi″bril]
one of the fine fibrils in epithelial cells, thought to give a supporting framework to the cell.

ton·o·fi·bril

(ton'ō-fī'bril),
One of a system of fibers found in the cytoplasm of epithelial cells. See: cytoskeleton, tonofilament.

tonofibril

/tono·fi·bril/ (ton´o-fi″bril) a bundle of fine filaments (tonofilaments) in certain cells, especially epithelial cells, the individual strands of which traverse the cytoplasm in all directions and extend into the cell processes to converge and insert on the desmosomes.

tonofibril

[ton′əfī′bril]
Etymology: Gk, tonos, stretching, fibrilla, small fiber
a bundle of fine filaments found in the cytoplasm of epithelial cells. The individual strands, or tonofilaments, spread throughout the cytoplasm and extend into the intercellular bridge to converge at the desmosome. The system of fibers functions as a supportive element within the cytoskeleton. In keratinizing epithelium the strands are the main precursor of keratin. Also called epitheliofibril, tenofibril. See also keratohyalin.

ton·o·fi·bril

(ton'ō-fī'bril)
One of a system of fibers found in the cytoplasm of epithelial cells.
See also: cytoskeleton

ton·o·fi·bril

(ton'ō-fī'bril)
One of a system of fibers found in the cytoplasm of epithelial cells.

tonofibril (ton´əfī´bril),

n a fibril emanating from epithelial cells. Recent electron microscopy has shown such fibrils to be irregular formations of the cell membrane.
Enlarge picture
Tonsil.

tonofibril

one of the fine fibrils in epithelial cells, thought to give a supporting framework to the cell.
References in periodicals archive ?
We believe that the positive expression of tumor cells for CK and other epithelial markers and the presence of tonofibrils and desmosomes are proportional to the degree of differentiation of squamous cell component existing in this neoplasm.
The histology (presence of glandular components in most cases), immunohistochemistry (variable expression for CK, endomysial antibody, and CEA), and EM data (rare tonofibrils, poorly formed desmosomes) as seen in our case and being reported in the literature confirmed the original belief that GCC is a poorly differentiated adenosquamous carcinoma.