Five case reports described staring spells and
tonic-clonic seizures in patients receiving 10 to 15 mg of aripiprazole.15"19 In the New Drug Application (NDA) for aripiprazole, the incidence of seizures was estimated to be .11% (1 of 926 patients) in placebo-controlled trials and .46% (3 of 859 patients) in haloperidol-controlled trials.
Seizures can be broadly classified as generalized (
tonic-clonic), focal (partial), and other, such as neonatal seizures or infantile spasms.
About 53 out of 54 generalised
tonic-clonic seizures were detected by Embrace for an accuracy rate of 98% during the clinical testing, with the overall FAR for adults being 0.67 and the one for paediatrics being 1.35.
Roughly 6,530 hours of data were recorded over 272 days, including 40 generalized
tonic-clonic seizures.
Data were expressed as mean[+ or -]standard error of mean (SEM) for the latency of clonic and generalized
tonic-clonic seizures.
This occurs most commonly in the setting of generalized
tonic-clonic seizures, where muscle contractions lead to adenosine monophosphate deamination and the subsequent production of ammonia [4].
Here, we present a woman with both RA and recurrent pregnancy loss probably due to a high titer of anti-phospholipid IgM antibody, but without hypertension, who suffered PRES with stroke (intracerebral and subarachnoid hemorrhage), accompanied by two
tonic-clonic seizures, occurring at 5 and 7 days after delivery.
The patients with generalized
tonic-clonic scored high on trait anxiety whereas patients with absence seizures scored high on trait of dominance.
SCs are more potent than marijuana (as much as 100 times stronger); do not contain the anti-anxiety and antipsychotic constituent of marijuana, cannabidiol; and have a greater risk of a range of adverse effects, such as tachycardia, agitation, nausea, generalized
tonic-clonic seizures, psychiatric problems, and death (Pediatrics.
The 46-year-old suffered the
tonic-clonic seizure - once known as a "grand mal".
During his hospitalization period, one of his sisters developed generalized
tonic-clonic seizure.