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an antispasmodic agent used in treatment of bladder hyperactivity.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Detrol, Detrol LA, Detrusitol (UK), Detrusitol XL (UK)

Pharmacologic class: Anticholinergic

Therapeutic class: Urinary tract antispasmodic

Pregnancy risk category C


Competitively antagonizes muscarinic receptors, inhibiting bladder contractions and reducing urinary frequency


Capsules (extended-release): 2 mg, 4 mg

Tablets: 1 mg, 2 mg

Indications and dosages

Overactive bladder

Adults: 2 mg (immediate-release) P.O. b.i.d.; may decrease to 1 mg P.O. b.i.d. depending on response and tolerance. Or 4 mg (extended-release) P.O. daily; may decrease to 2 mg P.O. daily, depending on response.

Dosage adjustment

• Hepatic impairment or disease

• Renal impairment

• Concurrent use of potent CYP3A4 inhibitors


• Hypersensitivity to drug, its components, or to fesoterodine fumarate extended-release tablets

• Urinary or gastric retention

• Uncontrolled angle-closure glaucoma


Use cautiously in:

• GI obstruction, significant bladder outflow obstruction, controlled angle-closure glaucoma, significant hepatic impairment, renal impairment

• pregnant or breastfeeding patients

• children (safety not established).


• Give with food to increase bioavailability.

Adverse reactions

CNS: headache, dizziness, vertigo, drowsiness, paresthesia, fatigue

CV: chest pain

EENT: vision abnormalities, xerophthalmia, pharyngitis

GI: diarrhea, constipation, abdominal pain, dyspepsia, dry mouth

GU: dysuria, urinary retention or frequency, urinary tract infection

Musculoskeletal: joint pain

Skin: dry skin

Other: weight gain, flulike symptoms, infection, anaphylaxis, angioedema


Drug-drug. Clarithromycin, erythromycin, itraconazole, ketoconazole, miconazole: inhibited metabolism and increased effects of tolterodine

Drug-food. Any food: increased drug bioavailability

Patient monitoring

Monitor patient for anaphylaxis and angioedema with first or subsequent doses. If difficulty breathing, upper airway obstruction, or fall in blood pressure occurs, discontinue drug and promptly provide appropriate treatment.

Monitor patient for signs and symptoms of anticholinergic CNS effects, particularly after beginning treatment or increasing dosage. Consider dosage reduction or drug discontinuation if symptoms occur.

• Monitor bladder function.

• Assess blood pressure and stay alert for chest pain.

• Monitor neurologic status. Report paresthesia or visual impairment.

Patient teaching

• Tell patient to take with food.

• If patient takes extended-release form, instruct him not to chew or crush it.

Instruct patient how to recognize and immediately report signs and symptoms of anaphylaxis or angioedema.

• Caution patient not to drive or operate heavy machinery until drug's effects are known.

• Advise patient to use sugarless gum or hard candy to relieve dry mouth.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs and foods mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


Detrol® Urology An agent used to manage overactive bladder Contraindications Urinary retention, gastric retention, narrow-angle glaucoma
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
(10) According to the results of this study, a combination of KH reduces the incidence of CRBD as much as 37%, which is greater than what other studies have ever found (oxybutynin (23% reduction), ketamine alone (30% reduction), and tolterodine (25% reduction)).
In the first quarter of 2000, the vast majority of users were treated with oxybutynin (68.6%; 10.4 users/1,000 beneficiaries) with the only other treatments being flavoxate (17.7%; 2.7 users/1,000 beneficiaries) and tolterodine (13.7%; 2.1 users/1,000 beneficiaries).
There is also concern with use of tolterodine (molecular weight about 476) because both the primary drug and its equipotent metabolite may be excreted into milk.
The EG animals were intragastrically injected with tolterodine (3.5 mg/kg, twice a day), CG animals were intragastrically injected with physiological saline, and the NC animals did not receive any treatment.
Because this condition is as a major cause of postoperative agitation (5), recent studies have evaluated various drugs in the prevention and treatment of CRBD, including ketamine (6), gabapentin (7), butylscopolamine (8), tramadol (9), oxybutynin, and tolterodine (4).
Some medications that fall into this class include older tricyclic antidepressants such as doxepin, antihistamines like Benadryl[R] (diphenhydramine), and medications such as Detrol[R] (tolterodine), which treats overactive bladder.
have each launched tolterodine tartrate extended-release capsules, described as generic versions of Detrol LA from Pfizer Inc., indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency and frequency.
(42) In a head-to-head comparison, both mirabegron 50 or 100 mg/day and tolterodine ER 4 mg/day improved key OAB symptoms from the first measured time point of 4 weeks and maintained efficacy throughout the 12- month treatment period.
Pharmaceutical company Mylan Inc (NasdaqGS:MYL) reported on Tuesday the launch of the the US Food and Drug Administration approved Tolterodine Tartrate Extended-release (ER) Capsules, 2 mg and 4 mg.
Therefore, we chose to examine trials comparing: mirabegron versus tolterodine, percutaneous tibial nerve stimulation versus tolterodine, and onabomlinumtoxinA versus anticholingeric medications.
Available agents include darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, and trospium.