Exemption for a "second line restricted" NSAID (nabumetone, piroxicam, tenoxicam, tiaprofenic acid, tolmetin
, sulindac, ketorolac, or diclofenac potassium) required failure on a first line restricted NSAID.
Effect of pH on acyl migration and hydrolysis of tolmetin
Three other Mylan products have been approved for marketing since March: nortriptyline HC1, a generic version of Sandoz' antidepressant Pamelor; sulindac, a version of Merck & Co.'s anti-inflammatory Clinoril; and tolmetin
sodium, a version of McNeil Pharmaceutical's anti-inflammatory Tolectin.
One randomized, double-blind, crossover trial compared single doses of tolmetin (Tolectin, 100, 150, 200 mg) and acetaminophen (400 mg) alone and in combination with placebo in the control of experimentally induced pain (thermal and electrical stimulation).
Effects of tolmetin, paracetamol, and of two combinations of tolmetin and paracetamol as compared to placebo on experimentally induced pain.
Aspirin may be low or intermediate risk, depending on the study, and tolmetin
and piroxicam may be intermediate or high risk.
In July the company began marketing tolmetin
sodium (the generic version of McNeil Pharmaceutical's Tolectin) in 600 mg.
In addition to services utilized, data were also collected on use of the following NSAIDs: aspirin, fenoprofen calcium, ibuprofen, indomethacin, naproxen, phenylbutazone, piroxicam, sulindac, and tolmetin
Aspirin 5 g/L Azathioprine 0.5 g/L Dexamethasone 1 g/L Diclofenac 5 g/L Etodolac 10 g/L Fenoprofen 5 g/L Flurbiprofen 0.05 g/L Gold thioglucose 10 g/L Hydroxychloroquine 5 g/L Ibuprofen 10 g/L Indomethacin 10 g/L Ketoprofen 1 g/L Meclofenamate 1 g/L Mefenamic acid 0.1 g/L Methotrexate 10 g/L Nabumentone 0.1 g/L Naproxen 5 g/L D-Penicillamine 1 g/L Piroxicam 5 g/L Prednisone 1 g/L Sulfasalazine 1 g/L Sulindac 5 g/L Tolmetin
10 g/L Table 4.
Peritoneal lavage fluid protease levels after in vivo administration of tolmetin
in hyaluronic acid.