Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
We believe that our proposed studies can clarify the mechanism by which group II PI3Ks control the interplay of endosomal traffic and the signalling by
Toll-like receptors. This might, in future, provide the rationale to develop drugs that could interfere with these processes, to ultimately combat diseases where the immune system is deregulated, such as inflammatory conditions.
Role of the innate immune system in host defence against bacterial infections: focus on the
Toll-like receptors. J Intern Med 2007; 261: 511-28.
Toll-like receptors: a family of pattern-recognition receptors in mammals.
Kaisho, "
Toll-like receptors: critical proteins linking innate and acquired immunity," Nature Immunology, vol.
Ohnishi, "Role of gut microbiota and
toll-like receptors in nonalcoholic fatty liver disease," World Journal of Gastroenterology, vol.
Yousefi, "
Toll-like receptors in the pathogenesis of autoimmune diseases," Advanced Pharmaceutical Bulletin, vol.
Dual role of
Toll-like receptors in asthma and chronic obstructive pulmonary disease.
This study aimed to investigate the kidney model of AKI caused by rhabdomyolysis to verify the role of macrophage
Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-?B) signaling pathway.
The
Toll-like receptor 2 R753Q mutation modifies cytokine production and
Toll-like receptor expression in atopic dermatitis.
Fifteen SNPs of the 7
Toll-like receptor gene (TLR1,2,3,4,5,6, and 9) were amplified by PCR using specific primers (Table 2).
Toll-like receptors are pattern-recognition receptors that play a role in the host defense against invading microbial pathogens.
