4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures.
We believe that our proposed studies can clarify the mechanism by which group II PI3Ks control the interplay of endosomal traffic and the signalling by Toll-like receptors
. This might, in future, provide the rationale to develop drugs that could interfere with these processes, to ultimately combat diseases where the immune system is deregulated, such as inflammatory conditions.
Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors
. J Intern Med 2007; 261: 511-28.
: a family of pattern-recognition receptors in mammals.
Kaisho, "Toll-like receptors
: critical proteins linking innate and acquired immunity," Nature Immunology, vol.
Ohnishi, "Role of gut microbiota and toll-like receptors
in nonalcoholic fatty liver disease," World Journal of Gastroenterology, vol.
Yousefi, "Toll-like receptors
in the pathogenesis of autoimmune diseases," Advanced Pharmaceutical Bulletin, vol.
Dual role of Toll-like receptors
in asthma and chronic obstructive pulmonary disease.
This study aimed to investigate the kidney model of AKI caused by rhabdomyolysis to verify the role of macrophage Toll-like receptor
4/nuclear factor-kappa B (TLR4/NF-?B) signaling pathway.
The Toll-like receptor
2 R753Q mutation modifies cytokine production and Toll-like receptor
expression in atopic dermatitis.
Fifteen SNPs of the 7 Toll-like receptor
gene (TLR1,2,3,4,5,6, and 9) were amplified by PCR using specific primers (Table 2).
are pattern-recognition receptors that play a role in the host defense against invading microbial pathogens.