To achieve this outcome, the inventors modified the cells' genomes to reduce the activity of genes that produce proteins that can provoke the transplant recipient's immune system, and to increase the activity of genes that produce tolerogenic
factors that signal "friend" not "foe."
EBVpositive large B-cell lymphomas in young patients: a nodal lymphoma with evidence for a tolerogenic
"Tumors employ various strategies to create a tolerogenic
microenvironment, which reduces the immune system's ability to detect and fight cancer," said Courtney Beers, Ph.D., Vice President, Immunology, Tizona.
The HLA-G molecule has indirect tolerogenic
roles by producing regulatory T cells (Treg)--cells that can inhibit other T cells.
Patrick Soon-Shiong, Chairman & CEO of NantKwest said, "High dose, uninformed, toxic chemotherapy damages the immune system and induces what is known as tolerogenic
Infants are highly susceptible to infectious diseases possibly due to immaturity of their immune system and susceptibility to tolerogenic
Heat shock protein 27 differentiates tolerogenic
macrophages that may support human breast cancer progression.
The UniverCyte technology uses the tolerogenic
molecule HLA-G, modified to be stably expressed on the cell extracellular membrane, to confer low immune observability to the resulting cells.
Macrophage and NK cells together induce tolerogenic
DCs (tDCs) (4), which per se promote Treg differentiation.
Day 1 Opening Address: "Mitigating the immunogenicity of AAV gene therapy vectors with tolerogenic
There are studies that indicate that vitamin D deficiency may cause food allergy allergy by causing impaired immunity balance, increased Th2 lymphocyte ratio, and decreased number of T regulatory and tolerogenic
dendritic cells, in addition to abnormal bowel barrier permeability (69).