tolbutamide


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Related to tolbutamide: acarbose, metformin

tolbutamide

 [tol-bu´tah-mīd]
a sulfonylurea used as a hypoglycemic in patients with type 2 diabetes mellitus whose blood glucose cannot be controlled by diet and exercise alone. The monosodium salt is used to test for insulinoma and diabetes mellitus.

tolbutamide

/tol·bu·ta·mide/ (tol-bu´tah-mīd) a sulfonylurea used as a hypoglycemic in the treatment of type 2 diabetes mellitus; the monosodium salt is used to test for insulinoma and diabetes mellitus.

tolbutamide

(tŏl-byo͞o′tə-mīd′)
n.
A sulfonylurea drug, C12H18N2O3S, used to treat type 2 diabetes.

TOLBUTamide

[tolbo̅o̅′təmīd]
an oral sulfonylurea antidiabetic.
indications It is prescribed in the treatment of stable type 2 diabetes uncontrolled by diet alone and for some patients changing from insulin to oral therapy.
contraindications Unstable diabetes, serious impairment of renal, hepatic, or thyroid function, pregnancy, or known hypersensitivity to this drug or to other sulfonylurea medications prohibits its use.
adverse effects Among the more serious adverse effects are hypoglycemia and skin reactions. Blood dyscrasias may occur.

tolbutamide

A drug used in the treatment of maturity-onset, non-insulin-dependent DIABETES. A brand name is Rastinon.

tolbutamide

oral hypoglycaemic agent stimulating synthesis and release of endogenous insulin from functional pancreatic islet cells

tolbutamide, (tolbū´təmīd´),

n brand name: Orinase;
drug class: sulfonylurea (first generation) oral antidiabetic;
action: causes functioning beta cells in pancreas to release insulin, leading to drop in blood glucose levels;
use: treatment of type II diabetes mellitus.

tolbutamide

a first generation sulfonylurea derivative, used as an oral hypoglycemic agent in the treatment of diabetes mellitus.

tolbutamide tolerance test
the blood sugar curve after an intravenous injection of the hypoglycemic agent tolbutamide parallels the curve in a glucose tolerance test.
References in periodicals archive ?
Analysis of tolbutamide pharmacokinetics was performed regardless of the CYP2C9 genotype for all subjects who completed the study.
Group-1V (diabetic rats) received antidiabetic agent tolbutamide (20 mg/kg b.
The ionization technique used was electrospray ionization (ESI) in the positive-ion mode for glibenclamide, glipizide, gliclazide, glibornuride, glimepiride, and carbutamide and in the negative-ion mode for chlorpropamide and tolbutamide.
Repaglinide and sulphonylureas such as tolbutamide bind with a receptor on pancreas cells called SUR1 ("sulphonylurea receptor 1"), thereby promoting insulin production.
For CYP2C9-mediated tolbutamide hydroxylation, the straight lines intersected in the first quadrant of Primary Lineweaver--Burk plots (Fig.
A 1962 paper reported 14 perinatal deaths in the offspring of 22 women taking chlorpropamide and 4 deaths in the offspring of 17 women taking tolbutamide.
Phenacetin, paracetamol, warfarin, tolbutamide, 4-hydroxy-methyltolbutamide, dextromethorphan, dextrorphan, chlorzoxazone, 6-hydroxyl-chiorzoxazone, testosterone, 6[beta]-hydroxyl testosterone, chlorpropamide, chlorpheniramine, [beta]-nicotinamide adenine dinucleotide phosphate (NADP), glucose-6-phosphate, glucose-6-phosphate dehydrogenase and other unspecified reagents were purchased from Sigma Chemical Co.
Tolbutamide (Orinase): Starting doses, 12 g/day (single or divided doses).
Previous studies have shown that PSP decreased antipyrine clearance and inhibited rat CYP2C11-mediated tolbutamide 4-hydroxylation and in human CYP2C9.
Phenacetin, paracetamol, warfarin, furafylline, testosterone, 613-hydroxytestosterone, ketoconazole, 4-hydroxytolbutamide, tolbutamide, chlorzoxazone, 6-hydroxychlorzoxazone, chlorpropamide, chlorpheniramine, dextromethorphan, dextrorphan, sodium diethyl-dithiocarbamate, glucose 6-phosphate dehydrogenase (G6PDH), D-glucose 6-phosphate (G6P), [beta]-nicotinamicle adenine dinucleotide phosphate (NADP), and Tris-HCI were purchased from Sigma Chemical Co.
The procedure is based on previously published methods (13-15) and has been optimized for identification, in a single analysis, of the most commonly prescribed SU drugs, including tolbutamide (TL), chlorpropamide (CL), glipizide (GP), gliclazide (GL), and glibenclamide (GB).