tolbutamide


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Related to tolbutamide: acarbose, metformin

tolbutamide

 [tol-bu´tah-mīd]
a sulfonylurea used as a hypoglycemic in patients with type 2 diabetes mellitus whose blood glucose cannot be controlled by diet and exercise alone. The monosodium salt is used to test for insulinoma and diabetes mellitus.

tolbutamide

(tŏl-byo͞o′tə-mīd′)
n.
A sulfonylurea drug, C12H18N2O3S, used to treat type 2 diabetes.

tolbutamide

A drug used in the treatment of maturity-onset, non-insulin-dependent DIABETES. A brand name is Rastinon.
References in periodicals archive ?
Comparative glucose tolerance test in 3 groups of normal rats namely Group I on Tinospora juice (400 mg/kg) as Test group; Group II on Tolbutamide (250 mg/kg) as Standard; and Group III on distilled water as Control group.
After 7 days, all rats were given a cocktail solution by oral administration containing five probe drugs: phenacetin (20mg/kg), tolbutamide (1mg/kg), omeprazole (20mg/kg), metoprolol (20 mg/kg), and midazolam (20 mg/kg).
In the 15th day, the mixed probe drugs containing caffeine, chlorzoxazone, tolbutamide, and midazolam were administered intravenously (by caudal vein) at a dosage of 2.5,5,5, and 5 mg/kg.
The retention times for IS, phenacetin, tolbutamide, chlorzoxazone, and testosterone were 5.28, 8.50, 6.70, 11.03, and 17.66 min, respectively (Figure 1(b)).
Test extracts (250 mg/kg b.w.), standard drug Tolbutamide (150 mg/kg b.w.), and control (2 mL saline) were administered orally, every 24 h for a period of 28 days.
Maincent, "Inclusion complexation of tolbutamide with [beta]-cyclodextrin and hydroxypropyl-[beta]-cyclodextrin," International Journal of Pharmaceutics, vol.
For example, in in vitro hippocampal slice preparation, K(+)-ATP channel blockers such as tolbutamide and glibenclamide produce neuroprotective effects [53].
The development of microchips for salivary components offers great possibilities to use oral fluid for point-of-care testing.13 Another fertile area of application for salivary analysis is in laboratory medicine, where determining and monitoring levels of various hormones (cortisol, progesterone, estriol, testoster-one etc.) and drugs (diazepam, caffeine, lithium, theophylline, tolbutamide, methotrexate, antibiotics, anticonvulsants, etc.) is becoming a conventional procedure.
Sulfonylureas 1% to 2% Widely used, Side effects: (e.g., lots of Hypoglycemia tolbutamide, clinical (incidence glyburide, experience.
1921'de insulinin kesfedilmesi ve 1955'te ilk oral antidiyabetiklerden tolbutamide ve carbutamide'in bulunmasi ile diabetes mellitus'un tedavisi mumkun olmus ve hastalarin yasam beklentileri uzamaya baslamistir.
gliclazide or tolbutamide) depends on adequate numbers of functioning [beta]-cells in the individual's pancreas, because it works primarily to increase secretion of insulin.
The first-generation sulfonylureas currently available are chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide (Orinase).