Comparative glucose tolerance test in 3 groups of normal rats namely Group I on Tinospora juice (400 mg/kg) as Test group; Group II on Tolbutamide
(250 mg/kg) as Standard; and Group III on distilled water as Control group.
After 7 days, all rats were given a cocktail solution by oral administration containing five probe drugs: phenacetin (20mg/kg), tolbutamide
(1mg/kg), omeprazole (20mg/kg), metoprolol (20 mg/kg), and midazolam (20 mg/kg).
In the 15th day, the mixed probe drugs containing caffeine, chlorzoxazone, tolbutamide
, and midazolam were administered intravenously (by caudal vein) at a dosage of 2.5,5,5, and 5 mg/kg.
The retention times for IS, phenacetin, tolbutamide
, chlorzoxazone, and testosterone were 5.28, 8.50, 6.70, 11.03, and 17.66 min, respectively (Figure 1(b)).
Test extracts (250 mg/kg b.w.), standard drug Tolbutamide
(150 mg/kg b.w.), and control (2 mL saline) were administered orally, every 24 h for a period of 28 days.
Maincent, "Inclusion complexation of tolbutamide
with [beta]-cyclodextrin and hydroxypropyl-[beta]-cyclodextrin," International Journal of Pharmaceutics, vol.
For example, in in vitro hippocampal slice preparation, K(+)-ATP channel blockers such as tolbutamide
and glibenclamide produce neuroprotective effects .
The development of microchips for salivary components offers great possibilities to use oral fluid for point-of-care testing.13 Another fertile area of application for salivary analysis is in laboratory medicine, where determining and monitoring levels of various hormones (cortisol, progesterone, estriol, testoster-one etc.) and drugs (diazepam, caffeine, lithium, theophylline, tolbutamide
, methotrexate, antibiotics, anticonvulsants, etc.) is becoming a conventional procedure.
Sulfonylureas 1% to 2% Widely used, Side effects: (e.g., lots of Hypoglycemia tolbutamide
, clinical (incidence glyburide, experience.
1921'de insulinin kesfedilmesi ve 1955'te ilk oral antidiyabetiklerden tolbutamide
ve carbutamide'in bulunmasi ile diabetes mellitus'un tedavisi mumkun olmus ve hastalarin yasam beklentileri uzamaya baslamistir.
gliclazide or tolbutamide
) depends on adequate numbers of functioning [beta]-cells in the individual's pancreas, because it works primarily to increase secretion of insulin.
The first-generation sulfonylureas currently available are chlorpropamide (Diabinese), tolazamide (Tolinase), and tolbutamide