tocotrienol


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to·co·tri·en·ol

(tō'kō-trī'en-ol),
A tocol with three double bonds in the side chain, that is, with three additional double bonds in the phytyl chain. The natural products carry methyls at one or more of positions 5, 7, and 8 of the chromanol and are thus identical, except for the unsaturation in the phytyl-like side chain, to the tocopherols; also analogous is the cyclization to form a chromanol derivative and oxidation to form the tocotrienolquinones (or chromenols). Abbreviated T-n (hydroquinone form) or TQ-n (quinone form) and preceded by α-, β-, etc., as in the tocopherols, to indicate degree of methylation (the n indicates the number of intact isoprene or prenyl units remaining in the chromanol or chromenol form). Tocotrienol terminology is used to indicate relationships to tocols and tocoenols (vitamin E-like), the chromanol terminology to indicate relationship to the isoprenoidal compounds of the vitamin K and coenzyme Q series.

tocotrienol

one of the eight structurally related compounds which are grouped together as vitamin E; tocotrienol indicates a compound with an unsaturated side chain.
References in periodicals archive ?
A unique pathway modulated by gamma tocotrienol is the mevalonate pathway that controls cholesterol production, cancer promotion, and bone formation.
It is anticipated that the technology will help improve the bioavailability of tocotrienols, which forms the basis of Gordagen's prescription medicines portfolio.
She added that it would be interesting to investigate the synergism and potential health benefits of oil palm phenolics, tocotrienols and the current standard pancreatic cancer drugs when taken together.
Two isomers of tocochromanols have been identified: tocopherol (a, AY, and d) and tocotrienol (a, AY, and d).
Group A was given normal laboratory diet, group B high fat diet and group C was given tocotrienol along with high fat diet for 32 weeks.
Tocotrienol rich fraction (TRF) is an extract of palm oil, and consists of 25% of [alpha]-TCP and 75% tocotrienols.
The stock solutions of various tocotrienol isomers were prepared in DMSO and were stored at -20[degrees]C until use.
Tocopherol standards were purchased from Merck and tocotrienol standards were acquired from Davos Life Science.
This is an important feature, since research of the past 20 years has shown alpha-tocopherol as a culprit in interfering with tocotrienol benefits, both cardiovascular and cancer.
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme.
The researchers found that plasma tocopherol and tocotrienol levels, in combination with automated MRI measurements can accurately help to differentiate MCI from AD patients, and to prospectively predict MCI conversion into AD.