tobramycin


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tobramycin

 [to″brah-mi´sin]
an aminoglycosideantibiotic produced by Streptomyces tenebrarius and used topically as the base to treat external infections of the eye, by oral inhalation to treat Pseudomonas aeruginosa infections in patients with cystic fibrosis, and intramuscularly or intravenously as the sulfate salt to treat a wide variety of infections.

tobramycin

/to·bra·my·cin/ (to″brah-mi´sin) an aminoglycoside antibiotic derived from a complex produced by Streptomyces tenebrarius, bactericidal against many gram-negative and some gram-positive organisms; also used as the sulfate salt.

tobramycin

Nebcin® A broad-spectrum aminoglycoside antibiotic effective against many gram-negative bacteria, in particular, Pseudomonas infections, unresponsiveness to penicillins or cephalosporins Adverse effects Ototoxicity, neurotoxicity, nephrotoxicity. See Therapeutic drug monitoring.

tobramycin

An antibiotic drug similar in use to Gentamicin, but useful in the treatment of gentamicin-resistant infections. A brand name is Nebcin.

antibiotic 

1. Pertaining to the ability to destroy or inhibit other living organisms.
2. A substance derived from a mould or bacterium, or produced synthetically, that destroys (bactericidal) or inhibits the growth (bacteriostatic) of other microorganisms and is thus used to treat infections. Some substances have a narrow spectrum of activity whereas others act against a wide range of both gram-positive and gram-negative organisms (broad-spectrum antibiotics). Antibiotics can be classified into several groups according to their mode of action on or within bacteria: (1) Drugs inhibiting bacterial cell wall synthesis, such as bacitracin, vancomycin and the β-lactams based agents (e.g. penicillin, cephalosporins (e.g. ceftazidime, ceftriaxone, cefuroxime). (2) Drugs affecting the bacterial cytoplasmic membrane, such as polymyxin B sulfate and gramicidin. (3) Drugs inhibiting bacterial protein synthesis, such as aminoglycosides (e.g. amikacin sulfate, framycetin sulfate, gentamicin, neomycin sulfate and tobramycin), tetracyclines, macrolides (e.g. erythromycin and azithromycin) and chloramphenicol. (4) Drugs inhibiting the intermediate metabolism of bacteria, such as sulfonamides (e.g. sulfacetamide sodium) and trimethoprim. (5) Drugs inhibiting bacterial DNA synthesis, such as nalixidic acid and fluoroquinolones (e.g. ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin). (6) Other antibiotics such as fusidic acid, the diamidines, such as propamidine isethionate and dibrompropamidine. Syn. antibacterial. See antiinflammatory drug; fusidic acid.

tobramycin (ophthalmic),

n brand name: Tobrax;
drug class: antiinfective;
action: inhibits bacterial protein synthesis;
use: treatment of infection of the eye.

tobramycin

an aminoglycoside antibiotic, similar to kanamycin and neomycin, produced by cultures of Streptomyces tenebrarius. Used as the sulfate.
References in periodicals archive ?
Similarly, Hanessian has reported the synthesis of a library of tobramycin analogues bearing various functionalities at 5-OH by the direct modification of tobramycin 3a-e (Fig.
To mimic the clinical environment, they stuck to the maximum possible tobramycin dose of 1,000 micrograms per milliliter, mixed with a chelator.
The target range for tobramycin dosing was a trough level less than 2 g/mL and peak level of 8 to 12 [micro]g/mL for dosing 2 to 3 times daily or 20 to 40 [micro]g/mL for once-daily dosing (Coulthard et al.
Since tobramycin use is restricted to human medical use only, resistance cannot have been caused by exposure.
Some practitioners also add rifampin to a regimen of tobramycin and ceftazidime because, although rifampin itself has little activity against P aeruginosa, laboratory studies suggest it may have synergy with the other two agents and therefore can help fight against mucoid colonization.
1]), was 62% in patients randomized to meropenem and tobramycin, compared with 44% in the cefrazidime/tobramycin group.
On the sixth hospital day, the Gram-negative bacillus was identified as Kluyvera species susceptible to tobramycin and resistant to ampicillin.
which provides it with the capability of developing and manufacturing injectable products for hospitals (such as cefazolin sodium and tobramycin sulfate).
OSTEOSET([R]) T is a surgical grade calcium sulfate bone graft substitute impregnated with 4 percent tobramycin sulfate.
The acquired products include Buprenorphine HCl/Naloxone HCl Sublingual Film, Ethinyl estradiol/Ethonogestrel Vaginal Ring, Ezetimibe/Simvastatin Tablets, Metformin HCl/Saxagliptin ER Tablets, Tobramycin Inhalation Solution, Phentermine HCl/Topiramate ER Capsules, Imiquimod Topical Cream and Ramelteon Tablets.