titin


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ti·tin

(tī'tin), [MIM*188840]
A very large fibrous protein that connects thick myosin filaments to Z discs in the sarcomere.

titin

A giant elastic protein with kinase activity that extends over half the length of a sarcomere and serves as a scaffold to which myofibrils and other muscle-related proteins attach.

titin

(tī′tĭn)
An elastic protein in sarcomeres that anchors myosin filaments to the Z disks.

titin

A protein in muscles cells that extends from the Z line to the thick filaments and M line of the SARCOMERE.
References in periodicals archive ?
Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin truncations in health and disease.
Flexibility and extensibility in the titin molecule: Analysis of electron microscope data.
As the unfolded immunoglobulin domains can not return to its original structure, this reduces the stiffness of the heart wall and titin can not play its part as a sensor of the mechanical stress of cardiomyocytes, which limits the pumping function of the heart.
The TITIN FORCE[TM] is the world's only weighted compression workout apparel system.
Regulation of skeletal muscle stiffness and elasticity by titin isoforms: a test of the segmental extension model of resting tension.
Since Titin is the largest protein ever discovered, its name had to be equally as large.
Stepwise unfolding of titin under force-clamp atomic force microscopy, Proc Natl Acad Sci U S A 2001; 98 (2): 468-472.
By the use of SDS gel electrophoresis, a decrease in molecular weight of titin in dilated cardiomyopathy compared with normal was revealed which is correlated with the stage of disease [12].
The road passing through mountains would connect the Titin area of Noorgram district with Wama and Nuristan-i-Markazi districts, Governor Tamim Nuristani told Pajhwok Afghan News.
8,29) Some of the commonly mutated genes causing the AD type of familial DCM include lamin A/C, betamyosin heavy chain, alphamyosin heavy chain, actin, alpha-actinin-2, metavinculin, desmin, sarcoglycan, troponin T, alpha-tropomyosin, titin and phospholamban.
For example, titin is a huge muscle protein that has been copied by researchers who have successfully created a molecule that can be stretched and then contracts again, just as titin does (Chaikof, 2010).