Integrated allelic, transcriptional, and phenomic dissection of the cardiac effects of titin
truncations in health and disease.
Glucocorticoid-induced alterations in titin
, nebulin, myosin
Flexibility and extensibility in the titin
molecule: Analysis of electron microscope data.
As the unfolded immunoglobulin domains can not return to its original structure, this reduces the stiffness of the heart wall and titin
can not play its part as a sensor of the mechanical stress of cardiomyocytes, which limits the pumping function of the heart.
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Regulation of skeletal muscle stiffness and elasticity by titin
isoforms: a test of the segmental extension model of resting tension.
is the largest protein ever discovered, its name had to be equally as large.
Stepwise unfolding of titin
under force-clamp atomic force microscopy, Proc Natl Acad Sci U S A 2001; 98 (2): 468-472.
By the use of SDS gel electrophoresis, a decrease in molecular weight of titin
in dilated cardiomyopathy compared with normal was revealed which is correlated with the stage of disease .
The road passing through mountains would connect the Titin
area of Noorgram district with Wama and Nuristan-i-Markazi districts, Governor Tamim Nuristani told Pajhwok Afghan News.
8,29) Some of the commonly mutated genes causing the AD type of familial DCM include lamin A/C, betamyosin heavy chain, alphamyosin heavy chain, actin, alpha-actinin-2, metavinculin, desmin, sarcoglycan, troponin T, alpha-tropomyosin, titin
For example, titin
is a huge muscle protein that has been copied by researchers who have successfully created a molecule that can be stretched and then contracts again, just as titin
does (Chaikof, 2010).