PLAT

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PLAT

A gene on chromosome 8p12 that encodes tissue plasminogen activator, which converts inactive plasminogen to plasmin by hydrolysing a single Arg-Val bond in plasminogen, thereby playing a key role in tissue remodelling, degradation, cell migration and other cellular events. PLAT directly facilitates neuronal migration.
References in periodicals archive ?
Huber et al., "The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator," Journal of Molecular Biology, vol.
Quality improvement and tissue-type plasminogen activator for acute ischemic stroke: a Cleveland update.
Methods: The cross-sectional case-control study compared circulating concentrations of high sensitivity C reactive protein (hsCRP), fibrinogen, tissue-type plasminogen activator (tPA), and plasminogen activator inhibitor-1 (PAI-1) between patients of acute myocardial infarction (AMI) (n = 67), Unstable Angina Pectoris (UA) (n = 35) and healthy control subjects (n = 39) at the King Khalid University Hospital, Riyadh, Saudi Arabia, from June 2006 to August 2007.
(25.) Bang CO, Park HK, Ahn MY, Shin HK, Hwang KY, Hong SY: 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene and insertion/deletion polymorphism of the tissue-type plasminogen activator gene in atherothrombotic stroke.
Recombinant tissue-type plasminogen activator versus a novel dosing regimen of urokinase in acute pulmonary embolism: a randomized controlled multicenter trial.
Cell-free mRNA concentrations of plasminogen activator inhibitor-1 and tissue-type plasminogen activator are increased in the plasma of pregnant women with preeclampsia.
In addition, compared with recombinant tissue-type plasminogen activator, desmoteplase does not appear to be neurotoxic, said Dr.
An endothelial storage granule for tissue-type plasminogen activator. Thromb.
BACKGROUND * Intravenous tissue-type plasminogen activator (tPA) benefits acute ischemic stroke patients if given within 3 hours.
The new study confirms that ethanol helps prevent dangerous internal blood clots that can block arteries by apparently raising blood levels of a natural enzyme called tissue-type plasminogen activator or TPA.
Coronary thrombo-lysis with intravenously administered human tissue-type plasminogen activator produced by recombinant DNA technology.