thromboplastin

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Related to tissue thromboplastin: Tissue factor

thromboplastin

 [throm″bo-plas´tin]
tissue thromboplastin factor III, a coagulation factor derived from several different sources in the body, such as brain and lung; it is important in the formation of extrinsic prothrombin converting principle in the extrinsic pathway of coagulation. Called also tissue factor. See also activated partial thromboplastin time.

throm·bo·plas·tin

(throm'bō-plas'tin),
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in coagulation of blood. It is now generally believed that thromboplastin activity may be developed through blood (intrinsic) or tissue (extrinsic) systems. Tissue thromboplastin (factor III) interacts with factor VII and calcium to activate factor X; active factor X combines with factor V in the presence of calcium and phospholipid to produce thromboplastin activity (also commonly called thromboplastin).

thromboplastin

(thrŏm′bō-plăs′tĭn)
n.
A protease that converts prothrombin to thrombin in the early stages of blood clotting. Also called thrombokinase.

throm·bo·plas·tin

(throm'bō-plas'tin)
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood; in the presence of calcium ions, thromboplastin is necessary for the conversion of prothrombin to thrombin, an important step in blood coagulation.
Synonym(s): platelet tissue factor, thrombokinase.

thromboplastin

Blood clotting factor III, an obsolete term referring to what is now known to be several blood clotting factors operating together.

thromboplastin

see BLOOD CLOTTING.

Thromboplastin

A protein in blood that converts prothrombin to thrombin.
Mentioned in: Prothrombin Time

throm·bo·plas·tin

(throm'bō-plas'tin)
A substance present in tissues, platelets, and leukocytes necessary for the coagulation of blood.
Synonym(s): platelet tissue factor, thrombokinase.
References in periodicals archive ?
In the 1998 revision (H21-A3), CLSI removed the recommendation to use a discard tube when drawing PT (prothrombin time) and APTT (activated partial thromboplastin time) tests, since studies showed tissue thromboplastin did not affect results when the sodium citrate tube was the first or only tube drawn using a tube holder.
Some recommended procedures for acquiring samples for coagulation analysis, especially those involving the measurement of D-dimer and fibrinogen by the Clauss method, mandate that the first sample be discarded because tissue thromboplastin released by the trauma of venipuncture could interfere with coagulation assays by activating intrinsic pathway (2).