Microcirculatory dysfunction and tissue oxygenation
in critical illness.
 investigated the effects of different tidal volume ventilation on cerebral tissue oxygenation
and metabolism in pig and found that low tidal volume (6 ml/kg) group significantly improved brain tissue oxygenation
and micrometabolism compared to high tidal volume (12 ml/kg) group.
also showed a statistically meaningful difference with 71 percent of high-dose VM202 patients showing increased TcPO2 levels.
It has been suggested that the improvement in tissue oxygenation
may be associated with improvement in the microcirculation.8 Popatov9 reported that the reason for a lower drop in mean arterial blood pressure in patients who were to undergo abdominal surgery to whom 1000ml 6% HES 130/0.4 solution was administered before epidural anaesthesia, was that stable haemodynamics were achieved without renal and haemostatic impairment and a reduced immune response was created.9 Dubin et al.12 determined an improvement in sublingual microcirculation from the application of fluid treatment with 6% HES 130/0.4 to septic patients in the early period.
The degree of fetal hypoxaemia in this case would have been disproportionate to the degree of anaemia seen in alloimmunised pregnancies, and the severe anaemia (resulting both from placental deprivation and recurrent blood loss) would have compromised the chronic poor fetal tissue oxygenation
The therapeutic objective of improving oxygenation is critically important in ACS, as the abnormal sickling hemoglobin (HbS) has behaviors well beyond what we learn in school about hemoglobin, its normal response to oxygen in the arterial blood, and hemoglobin's role in tissue oxygenation
The role of tissue oxygenation
in wound healing became the focal point in the 1980s.
Asphyxia (from the Greek words a "without" and sphyxis, "heartbeat") is a condition of deficient tissue oxygenation
leading to hypoxia with different etiologies.
A compromised airway presents a significant hazard to any form of anaesthesia, especially if it results in cardio-respiratory depression, which will expedite hypoxemia and impair tissue oxygenation
. An awake, spontaneously ventilating approach to secure the airway needs to be undertaken.
The present results showing reduced intercostal and forearm perfusion and tissue oxygenation
in patients with HF could be explained by mechanisms other than the activation of the respiratory metaboreflex operating during the respiratory fatigue protocol, such as reduction of overall tissue perfusion and decrease in Sp[O.sub.2].
Local tissue oxygenation
and blood flow are essential to maintain tissue viability.
Ethyl alcohol has the ability to satisfy hunger and reduce the intake of nutrients, resulting in greater skin fragility, accelerating the rate of scaling, diminishing superficial and deep tactile sensitivity, and decreasing tissue oxygenation
. (2) Ethyl alcohol consumes, for its metabolism, large amounts of vitamins that influence wound healing.