tissue macrophage

tissue macrophage

Etymology: OFr, tissu + Gk, makros, large, phagein, to eat
a large, mobile, highly phagocytic cell derived from monocytes. These cells become mobile when stimulated by inflammation and migrate to the affected area. They are resident in specific tissues (for example, alveolar macrophages in the lungs).
References in periodicals archive ?
Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated bythe over-expression of tissue macrophage inflammatory protein-2 mRNA.
The metabolic improvements correlated with a significant reduction in adipose tissue macrophage numbers.
Changes in the tissue distribution of carbon with time suggest that blood monocytes and tissue macrophages are mobile and constantly transport foreign matter to the peripheral lymphoid tissues.
Human adipose tissue macrophages are of an anti-inflammatory phenotype but capable of excessive pro-inflammatory mediator production.
Mice were euthanized, airway cells were collected from lungs at indicated time points by bronchoalveolar lavage (BAL), and the remaining live cells were quantified and stained for fluorescence-activated cell sorting (FACS) analysis to detect neutrophils (Gr1), eosinophils (Fc[epsilon]RI[alpha]), T lymphocytes (CD3, CD4, and CD8), B cells (B220), alveolar macrophages (CD11c), and tissue macrophages (CD11b), as previously described (Beaver et al.
IL-6 and TNF-alpha are produced and secreted mainly by activated tissue macrophages in response to injury or infection, and act on endothelial cells at the DNA transcription level.
In healthy normal brain, microglia are present in an inactive phase as compared with other tissue macrophages, but subtle microenvironmental changes can induce microglia to react rapidly, change morphology and acquire an array of functions, including phagocytosis and secretion of inflammatory mediators.
We propose that a single term, xanthogranulomatosis, replace the varied terms currently used to describe the syndromes in avian species in which intracytoplasmic lipid is found within tissue macrophages.
The virus replicates cytocidally in a subpopulation of permissive tissue macrophages that clears excess lactate dehydrogenase from circulation.
3] Cells of the mononuclear phagocyte system (MPS), including tissue macrophages and blood monocytes, are prominent targets of Ebola viruses.
Tissue macrophages in the localized areas ingest the escaped particles, degrade them to lipids, and release the lipids into extracellular spaces.