Histiocytic disorders are a group of diseases that occur when there is an overproduction of tissue macrophage
cells known as histiocytes.
ADMSC: adipose mesenchymal stem cell; PC1: Prohormone Convertase 1; ILC-2: group 2 innate lymphoid cells; BMP7: bone morphogenic protein 7; EID1: EP300-interacting inhibitor of differentiation 1; M2 ATM: adipose tissue macrophage
2; FGF21: fibroblastic growth factor 21; PPARg: peroxisome proliferator-activated receptor gamma; TR: thyroid receptors; FXR: farnesoid X receptor; BNP: brain natriuretic factor.
Saltiel, "Obesity induces a phenotypic switch in adipose tissue macrophage
polarization," The Journal of Clinical Investigation, vol.
Oral exposure to cadmium chloride triggers an acute inflammatory response in the intestines of mice, initiated bythe over-expression of tissue macrophage
inflammatory protein-2 mRNA.
Abnormal differentiation of tissue macrophage
populations in osteopetrosis (op) mice defective m the production of macrophage colony-stimulanting factor.
We want to understand the age-associated changes in gene expression and epigenetic identity of tissue macrophage
populations with the ultimate goal to reverse age dependent decline in self-renewal and function.
CSF1R, a cell-surface receptor for its ligands, colony-stimulating factor 1 and IL-34, is thought to play an important role as regulator of the development, morphology, survival, and functions of tissue macrophages
as well as tumor-associated macrophages.
This is the first report demonstrating that tissue macrophages
can be infected and that they respond to antiretroviral therapy,' Honeycutt said.
The first wave of macrophages is generated during early embryogenesis and is derived from Yolk Sac progenitors, giving rise to physiological tissue macrophages
(named microglia, Langerhans cells, Kupffer cells and alveolar macrophages) with the marked ability to self-renew in the periphery.
(TiMas) continuously phagocytize and digest apoptotic cells and tissue debris.
Apoptotic or aged neutrophils are cleared primarily by resident tissue macrophages
in the liver, spleen, and bone marrow [10,11].
Whether tissue macrophages
are self-renewing or continuously replenished from the bone marrow still is a matter of debate.