kallikrein

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Related to tissue kallikrein: kallikrein serine protease 1

kallikrein

 [kal″ĭ-kre´in]
any of several serine endopeptidases that cleave kininogens to form kinins.
plasma kallikrein a hydrolytic enzyme of the plasma that cleaves HMW (high-molecular-weight) kininogen to produce bradykinin. It also activates several blood coagulation factors and plasminogen. It is formed from prekallikrein by activated coagulation factor XII.
tissue kallikrein a hydrolytic enzyme that cleaves LMW kininogen to produce kallidin. It and closely related forms are found in tissues and various glandular secretions such as lymph, pancreatic juice, urine, and saliva.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

kal·li·kre·in

(kal'i-krē'in),
A group of enzymes (for example, plasma, tissue, pancreatic, urinary, or submandibular kallikrein) that converts kininogen by proteolysis to bradykinin or kallidin. Trypsin and plasmin can also effect the conversion. Plasma kallikrein activates factor XII and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Farlex Partner Medical Dictionary © Farlex 2012

KLK4

A gene on chromosome 19q13.41 that encodes a serine protease expressed in the prostate.

Molecular pathology
Mutations of KLK4 cause amelogenesis imperfecta hypomaturation type 2A1.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes (e.g., plasma, tissue, pancreatic, urinary, submandibular kallikrein) that can convert kininogen by proteolysis to bradykinin or kallidin; trypsin and plasmin can also effect the conversion; plasma kallikrein activates the Hageman factor and acts on kininogen. Tissue kallikrein is a serine endopeptidase that can generate kallidin from kininogen.
Synonym(s): kininogenase, kininogenin.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

Kallikrein

Any of a group of compounds in the body known as serine endopeptidases that help to break down proteins into smaller units. Prostate-specific antigen belongs to this group of chemicals. A recently discovered kallikrein may be useful as a biomarker for ovarian cancer.
Mentioned in: Ovarian Cancer
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.

kal·li·kre·in

(kal'i-krē'in)
A group of enzymes that can convert kininogen by proteolysis to bradykinin or kallidin.
Medical Dictionary for the Dental Professions © Farlex 2012
References in periodicals archive ?
The new human tissue kallikrein gene family: structure, tunction, and association to disease.
Bode, "Structural basis of the zinc inhibition of human tissue kallikrein 5," Journal of Molecular Biology, vol.
Chao, "Kallistatin: a novel human tissue kallikrein inhibitor.
We hypothesized that the combined therapy could protect against hyperglycemia-induced chronic renal impairments through renal tissue kallikrein system activation and inflammatory pathway inhibition.
The interaction of [a.sub.1]-proteinase inhibitor and tissue kallikrein in controlling allergic ovine airway hyperresponsiveness.
Chao, "Localization and expression of tissue kallikrein and kallistatin in human blood vessels," Journal of Histochemistry & Cytochemistry, vol.
Creutzburg et al., "Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)," Biological Chemistry, vol.
Association of the tissue kallikrein gene promoter with ESRD and hypertension.
Kinins derived from kininogen produced by tissue kallikrein (TK) exert a broad spectrum of cellular functions via activation of the bradykinin B1 or B2 receptor (B1R or B2R, resp.) [14].