tissue factor pathway inhibitor


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tissue factor pathway inhibitor

(extrinsic factor) lipoprotein-associated coagulation inhibitor Hematology A coagulation factor X-dependent inhibitor of the factor VIIa/tissue factor complex; it is a plasma lipoprotein that regulates procoagulant effects of tissue factor; with Ca2+ and phospholipid, TFPI binds to and inhibits either free factor Xa or factors Xa and VIIa when associated with tissue factor-factor VIIa-Xa complex
References in periodicals archive ?
Lupu, "Expression, localization, and activity of tissue factor pathway inhibitor in normal and atherosclerotic human vessels," Arteriosclerosis, Thrombosis, and Vascular Biology, vol.
Assessment of the safety of recombinant tissue factor pathway inhibitor in patients with severe sepsis: a multicenter, randomized, placebo-controlled, single-blind, dose escalation study.
Plasma levels of total tissue factor pathway inhibitor are significantly related with the presence and severity of CAD.
Plasma tissue factor and tissue factor pathway inhibitor in patients with primary glomerulonephritis.
[3] Nonstandard abbreviations: TF, tissue factor; FVIIa, activated factor VII; TM, thrombomodulin; PC, protein C; EPCR, endothelial protein C receptor; APC, activated PC; PS, protein S; AT, antithrombin; TFPI, tissue factor pathway inhibitor; tPA, tissue plasminogen activator; uPA, urokinase plasminogen activator; PAI, plasminogen activator inhibitor; PI, plasmin inhibitor; TAFI, thrombin activatable fibrinolysis inhibitor; ROTEM/TEG, thromboelastometry/thromboelastography; T2MR, T2 magnetic resonance.
Increases activity of coagulation inhibitors such as antithrombin (AT) and tissue factor pathway inhibitor (TFPI)
The study represents the first scientific journal publication by EntreMed scientists on Tissue Factor Pathway Inhibitor (TFPI), a naturally occurring anticoagulant molecule.
However, inmyexperience, heparinase is not useful for evaluating prolonged PTs, because even when it is known that the PT prolongation is due to heparin, the heparinase is unable to correct the PT to reference interval values, possibly because of the increase in tissue factor pathway inhibitor that occurs with heparin therapy (2).
In total, EntreMed researchers gave nine presentations of the company's own research on its antiangiogenic product candidates and their respective effects in preclinical cancer models at the American Association for Cancer Research Annual Meeting, including two from the company's internal discovery program -- "Enantiomeric, Dependent Antimetastatic Activity of a Stable Thalidomide Analog," and "Tissue Factor Pathway Inhibitor Is an Inhibitor of Angiogenesis." A complete list of EntreMed's scientific study abstracts is attached.
Other modifiers of the rate of thrombin generation are the inhibitors: tissue factor pathway inhibitor, antithrombin, and other proteinase inhibitors.