tirofiban


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tirofiban

 [ti″ro-fi´ban]
a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves; administered intravenously.

tirofiban

/ti·ro·fi·ban/ (ti″ro-fi´ban) a platelet inhibitor, used as the hydrochloride salt in prophylaxis of thrombosis in unstable angina or in myocardial infarction that is not characterized by abnormal Q waves.

tirofiban

an antiplatelet agent.
indication It is used to treat acute coronary syndrome.
contraindications The following factors prohibit its use: known hypersensitivity to this drug, active internal bleeding, stroke, major surgery, severe trauma, intracranial neoplasm, aneurysm, and hemorrhage.
adverse effects Bleeding is a life-threatening effect of tirofiban. Other adverse reactions include bradycardia, dizziness, dissection, coronary artery edema, pain in the legs and/or pelvis, and sweating. Rash is a common side effect.

tirofiban

Aggrastat®, MK-383 Cardiology A potent short-acting, nonpeptide inhibitor of platelet glycoprotein IIb/IIIa or integrin αIIbβ3 receptor which, when administered with heparin, ↓ ischemic events in Pts with acute coronary syndrome. See PRISM, PRISM-PLUS.

tirofiban

An anticoagulant drug with the brand name Aggrastat. See SAW-SCALED VIPER VENOM.

antiplatelet therapy

agents that reduce platelet aggregation and inhibit arterial thrombus formation in an area of the circulation where other anticoagulants have reduced effect; e.g. low-dose aspirin (75 mg daily), clopidogrel (± low-dose aspirin), dipyridamole (used to prevent thromboembolism in patients with prosthetic heart valves), abciximab, eptifibatide and tirofiban
References in periodicals archive ?
In this study, platelet function analysis was performed using the Multiplate(r) platelet analyser (Dynabyte, Munich, Germany), whole blood impedance aggregometer which was proved to be sensitive for all three classes of commonly applied platelet function inhibitors: COX inhibitors (aspirin(r)), ADP receptor antagonists (Clopidogrel, Prasugrel, Cangrelor) and IIb/IIIa antagonists (Reopro(r), tirofiban, Integrilin(r)).
Oral antiplatelet drugs, aspirin and clopidogrel (Plavix), are prescribed in combination with warfarin and enoxaparin to prevent secondary thrombosis, (6) while the intravenous platelet inhibitors eptifibatide (Integrelin), abciximab (Rheopro), and tirofiban (Aggrastat) are used during PCI to maintain patency.
Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q wave myocardial infarction [erratum appears in N Engl J Med 1998;339:415].
Adding a high-dose (25 [micro]g/kg) bolus infusion of tirofiban to standard drug therapy just before high-risk percutaneous coronary interventions cut the rate of ischemic complications in a preliminary (phase II) study.
Tirofiban (Aggrastat), rated B; crosses the placenta, but animal studies show no evidence of fetal harm.
4-6] It has recently been demonstrated by several in vitro studies that antagonists of GPIIb/IIIa (Abciximab, Tirofiban, and Eptifibatide) are able to inhibit platelet aggregation induced by the serum of patients with HIT II.
The limitations of dual antiplatelet therapy with aspirin and clopidogrel have been further illustrated by the on-TIME-2 trial, in which patients undergoing primary PCI were randomised to additional prehospital tirofiban or placebo (42).
All of these patients were also treated with aspirin, heparin, and tirofiban.
In high-risk patients who aren't headed off for immediate catheterization, however, the new guidelines recommend only the small-molecule IIb / IIIa inhibitors eptifibatide and tirofiban.