tinidazole


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tinidazole

Fasigyn, Tindamax

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category C

FDA Box Warning

Prolonged use of metronidazole (a structurally related drug with similar biologic effects) has caused cancer in mice and rats. Reserve tinidazole for conditions listed under "Indications and dosages."

Action

Free nitro radical (generated from tinidazole reduction by Trichomonas cell extracts) may explain activity against Trichomonas species; activity against Giardia and Entamoeba species is unknown.

Availability

Tablets: 250 mg, 500 mg

Indications and dosages

Trichomoniasis caused by Trichomonas vaginalis

Adults: Single dose of 2 g P.O. with food, given to both sexual partners simultaneously

Bacterial vaginosis in nonpregnant females

Adults: 2 g P.O. once daily with food for 2 days, or 1 g P.O. once daily with food for 5 days

Giardiasis caused by Giardia duodenalis (Giardia lamblia)

Adults: Single dose of 2 g P.O. with food

Children older than age 3: Single dose of 50 mg/kg (up to 2 g) with food

Amebiasis caused by Entamoeba histolytica

Adults: 2 g P.O. daily with food for 3 days

Children older than age 3: 50 mg/kg (up to 2 g) P.O. daily with food for 3 days

Amebic liver abscess caused by E. histolytica

Adults: 2 g P.O. daily with food for 3 to 5 days

Children older than age 3: 50 mg/kg (up to 2 g) P.O. daily with food for 3 to 5 days

Dosage adjustment

• Hemodialysis patients

Contraindications

• Hypersensitivity to drug, its components, or other nitroimidazole derivatives

• First trimester of pregnancy

Precautions

Use cautiously in:

• CNS disease, hepatic dysfunction

• history of blood dyscrasias

• elderly patients

• pregnant or breastfeeding patients

• children (except to treat giardiasis and amebiasis in children older than age 3).

Administration

• Give with food to minimize GI discomfort.

Adverse reactions

CNS: weakness, fatigue, malaise, dizziness, vertigo, ataxia, insomnia, drowsiness, giddiness, headache, transient peripheral neuropathy, seizures

CV: palpitations

GI: nausea, vomiting, diarrhea, constipation, dyspepsia, gastric discomfort, tongue discoloration, stomatitis, anorexia

Hematologic: transient neutropenia and leukopenia

Musculoskeletal: arthralgia, myalgia, arthritis

Other: altered taste, overgrowth of susceptible organisms, hypersensitivity reactions including angioedema

Interactions

Drug-drug. Cyclosporine, lithium, tacrolimus: possible increase in blood levels of these drugs

Cholestyramine: decreased oral bioavailability of tinidazole

CYP450 inducers (such as phenobarbital, rifampin): increased tinidazole elimination and decreased blood level

CYP450 inhibitors (such as cimetidine, ketoconazole): increased tinidazole blood level

Fluorouracil: decreased fluorouracil clearance

Fosphenytoin, phenytoin: prolonged half-life and reduced clearance of these drugs

Oxytetracycline: antagonism of therapeutic effects of tinidazole

Warfarin, other oral coumarin anticoagulants: increased effects of these drugs

Drug-diagnostic tests. Alanine aminotransferase, aspartate aminotransferase, hexokinase glucose, lactate dehydrogenase, triglycerides: interference with test results

Drug-behaviors. Alcohol use: disulfiram-like reaction during tinidazole therapy and for 3 days after

Patient monitoring

Closely monitor patient for neurologic abnormalities, such as seizures and peripheral neuropathy. If these occur, withdraw drug immediately.

• Monitor blood chemistry tests, especially liver function tests.

Patient teaching

• Advise patient to take drug with food.

• For child or other patient unable to swallow tablets, inform parent or caregiver that drug can be crushed in artificial cherry syrup and given with food.

Caution patient or caregiver to stop therapy and call prescriber immediately if seizures or numbness or tingling in extremities occurs.

• Instruct patient to avoid alcohol use during therapy.

• Advise female patient to avoid pregnancy during therapy.

• Counsel female patient to avoid breastfeeding during therapy and for 3 days after last dose.

• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, and behaviors mentioned above.

tinidazole

an antiprotozoal.
indications This drug is used to treat amebiasis, giardiasis, and trichomoniasis.
contraindications First-trimester pregnancy and known hypersensitivity to nitroimidazole derivative or to this drug prohibit its use.
adverse effects Adverse effects of this drug include anorexia, increased aspartate aminotransferase and alanine aminotransferase, constipation, abdominal pain, neutropenia, pruritus, urticaria, and oral monilia. Life-threatening side effects include seizures, leukopenia, and angioedema. Common side effects include dizziness, headache, peripheral neuropathy, nausea, vomiting, and rash.

tinidazole

Parasitology An antiprotozoal used to treat amebiasis, giardiasis, trichomoniasis, and H pylori infections in Pts with low-grade gastric lymphoma

tinidazole

An antibacterial and antiprotozoal drug similar to METRONIDAZOLE but with a longer duration of action. It is used to treat AMOEBIASIS, TRICHOMONIASIS and GINGIVITIS. A brand name is Fastigyn.

tinidazole

an analog of metronidazole with a longer half-life but similar activity and uses.
References in periodicals archive ?
Any of oral metronidazole 2 g orally stat, oral tinidazole 2 g orally stat, or metronidazole 500mg orally twice a day for 7 days, can be prescribed.
Metronidazole and tinidazole are approved for use in all the above mentioned disorders including amoebic liver abscess.
Tinidazole, the only other recommended drug for trichomoniasis, is closely related to metronidazole, and there are essentially no data on cross-reactivity.
Thus we can only presume that he might have sensitivity to any of the components of the different FDCs he consumed, namely tinidazole or ornidazole (but not to metronidazole), and ciprofloxacin or ofloxacin.
After acquiring all the information and per rectal examination animals were treated for septic metritis with combinations of drugs like Ciprofloxacin and Tinidazole combination (Cflox Tz IU (a)) @ 60 ml intrauterine.
For those who fail treatment, longer courses of metronidazole or tinidazole are recommended by the Centers for Disease Control and Prevention (CDC).
Summary: TEHRAN (FNA)- Iranian researchers at Sharif University of Technology synthesized glass carbon electrode modified with a thin film of carbon nanotubes and gold nanoparticles, and used it as a nano-sensor to detect and measure tinidazole medicine with a precision of 10 nanomolars.
Metronidazole has been the mainstay of treatment for several decades; however, tinidazole has better in vitro activity and is well tolerated (8).
The list of alternative regimens for treating bacterial vaginosis now includes tinidazole 2 g orally once daily for 2 days or tinidazole 1 g orally once daily for 5 days.
The study carried out in two hospitals -- Ujjain Charitable Trust Hospital in Ujjain and Chandrikaben Rashmikant Gardi Hospital at Surasa -- in Madhya Pradesh found water discharged as effluent carried many types of commonly used antibiotics such as ciprofloxacin, metronidazole, norfloxacin, sulphamethoxazole, ceftriaxone, ofloxacin, levofloxacin and tinidazole.