The residual lymph node showed reactive germinal centers and tingible
body macrophages, but no hemophagocytosis (Figure 1).
9) Frequent mitotic figures, apoptotic bodies, and intermixed tingible
body macrophages (a "starry-sky" appearance) are also characteristic of PBL, regardless of site.
The tumor tissue contained tingible
body macrophages with nuclear debris.
In addition, tingible
body macrophages contain "ingested nuclear debris, which represents lymphocytes that have been selected to be destroyed in reactive follicles.
Secondary follicles form when primary follicles react to antigen stimulation and are characterized by a peripheral mantle zone of small mature B cells surrounding a central germinal center made up of antigen-selected centroblasts and centrocytes that segregate into polarized dark and light zones, respectively, with admixed tingible
body macrophages and follicular dendritic cells (Figure 1, C).
Reactive lymphadenitis was second most common finding with 13(26%) cases showing predominantly small lymphocytes, transforming lymphocytes, centrocytes, centroblasts, tingible
body macrophages and few histiocytes.
body macrophages will often impart the classic "starry-sky" pattern at low magnification.
Smears from fine needle aspiration of the mass lesion predominantly showed small and large lymphocytes, tingible
body macrophages admixed with fibrotic strands in haemorrhagic background (Figure 2 A and B).
Review at VUMC of the H&E-stained slides for the original low-grade lymphoma of patient 1 revealed a lymph node entirely effaced by a population of small lymphocytes in a predominantly diffuse pattern, with focal organization into round follicles with absent zonation, markedly attenuated mantle zones, and lack of tingible
They form irregular shapes and lack polarization, tingible
body macrophages, and normal mantle zones.
Apoptotic bodies and tingible
body macrophages were present in the background, imparting the starry sky" appearance.
Typically, reactive germinal centers show polarity (with light and dark zones) and have tingible