Tigroid pattern of cerebral white matter involvement in chromosome 6p25 deletion syndrome with concomitant 5p15 duplication.
Tigroid and leopard skin appearance in acute disseminated encephalomyelitis.
The absence of the characteristic facial rash also excluded RTS as the diagnosis.10 The hallmark radiological findings in XP-CS patients include intracranial calcifications, brain atrophy and tigroid
demyelination; two of these are present in the index case.
In addition, the background of fundus in high myopia and tigroid
fundus usually interfere with the evaluation of RNFL.
An MRI scan of the brain revealed cortical demyelination with tigroid appearance which confirmed the diagnosis of Metachromatic leukodystrophy.
Keywords: Metachromatic leukodystrophy, Motor regression, Tigroid.
T1: affected areas were low signaled while T2: affected areas were high signaled sparing along the venules, with some tigroid pattern (suggestive of metachromatic leukodystrophy) (Figure-2)
Four cases were Metachromatic Leukodystrophy with imaging findings of symmetric periventricular white matter T2/FLAIR hyperintensities with one case showing the typical Tigroid pattern due to sparing of perivascular white matter.
Metachromatic leukodystrophy has predominant periventricular white matter involvement with tigroid pattern and spares the subcortical U fibres until late in the disease.
The typical imaging appearance of PMD is nearly complete lack of myelination with tigroid appearance due to sparing of perivascular white matter.
Another common finding is reticular subretinal pigmentation, which is of no pathological significance Some people, with completely healthy eyes, show an interesting striped pigmentation to the fundus, known as a tigroid
Smudged nuclei, tigroid
appearance and RBCs were seen in the background (Figure 1).