tight junction


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Related to tight junction: gap junction, Desmosomes, Adherens junction

zo·nu·la oc·clu·'dens

tight junctions formed by the fusion of integral proteins of the lateral cell membranes of adjacent epithelial cells, limiting transepithelial permeability.

tight junction

[tīt]
Etymology: ME, thight, strong; L, jungere, to join
the zonula occludens of the junctional complex between cells in which the plasma membranes of adjacent cells are in direct contact and where there is no intercellular space.
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Tight junction

tight junc·tion

(tīt jŭngk'shŭn)
An intercellular junction between epithelial cells in which the outer leaflets of lateral cell membranes fuse to form a variable number of parallel interweaving strands that greatly reduce transepithelial permeability to macromolecules, solutes, and water through the paracellular route.

tight junction 

Refers to cells in which their membranes are fused rather than separated by a small extracellular space. The movement of substances through that space is restricted. Syn. zonulae occludentes. See blood-brain barrier.

tight junction

a cell junction in which there is no intercellular space between cell membranes and so is impermeable. See also cell junction.
References in periodicals archive ?
ZO-2 silencing in epithelial cells perturbs the gate and fence function of tight junctions and leads to an atypical monolayer architecture.
Effects of dietary Ala-Gln and Gln supplementation on the mRNA expression of tight junction proteins in the jejunum mucosa of piglets (n = 3).
Toborek, "HIV-1 Tat protein alters tight junction protein expression and distribution in cultured brain endothelial cells," Journal of Neuroscience Research, vol.
3D collagen scaffolds led to a significant increase in tight junction marker, such as claudin.
12F, a tight junction strand formed by the conserved hydrophobic residue that protrudes from the ECH in one protomer fits snugly into the hydrophobic pocket formed by TM3 and ECS2 in the adjacent protomer (Fig.
Tight junctions in thyroid carcinogenesis: diverse expression of claudin-1, claudin-4, claudin-7 and occludin in thyroid neoplasms.
The opening of tight junctions can allow undigested proteins and perceived invaders into the blood, triggering an immune response as the body reacts each time the proteins appear.
The observations from in vitro Caco-2 cell showed that the absorption of phenylethanoid glycosides in Fructus Forsythiae extract so with that in monomers was mainly restricted by the tight junctions, and influenced by efflux transporters (P-gp and MRP2).
Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice.
Using CISH technique showed that intestinal tight junction express mRNA Occludin after LPS induced rats getting probiotic LIS 20506 supplementation for 3 days (Figure 2).
Transmission electron microscopy also revealed that GTPs could reverse the opening of tight junction (TJ) barrier at 60 min and 120 min after MACO.
Barriers and channels formed by tight junction proteins 1.