A combinational therapy of ticarcillin
and clavulanate acid paired with an aminoglycoside, amikacin, has been introduced as an antibiotic regiment for Pseudomonas aeruginosa, a pathogenic bacteria, infections.
Pseudomonas S - - S stutzeri Pseudomonas S - - S putida Bacterial Antibiotic susceptibility test results species Tetracycline Ticarcillin
Tobramycin Trim/Sulfa Pseudomonas S S S S fluorescens Pasteurella - - - - multocida Serratia S S S S spp.
Susceptibility profile was tested by disc-diffusion agar (CLSI 2009) with the following drugs: amikacin, ampicillin, ampicillin + sulbactam, cephalothin, cefoxitin, cefpime, caeftazidime, ceftriaxone, gentamicin, imipenem, meropenem, piperacillin, quinolones, and sulfazotrim ticarcillin
+ clavulanic acid (Table 1).
aeruginosa may be treated with antimicrobial agents from three major groups based on mechanism of action: aminoglycosides (interference with protein synthesis) such as tobramycin or amikacin; beta-lactams (inhibition of cell wall synthesis) such as piperacillin, ticarcillin
, 3rd and 4th generation cephalosporins (ceftazidime and cefepime), and carbapenems like imipenem or meropenem; or fluoroquinolones (ciprofloxacin) (interference with nucleic acid replication).
8) The first is the SHV-1 [beta]-lactamase that is present in virtually all Klebsiella pneumoniae and confers resistance to ampicillin and ticarcillin
2002) analyzed renally cleared drugs: ampicillin, cimetadine, furosemide, piperacillin, ticarcillin
, tobramycin, vancomycin.
For each sample, 1 disk contained cefotaxime, ceftazidime, or cefepime, and a second disk contained ticarcillin
and clavulanate (10).
aeruginosa include piperacillin, ticarcillin
, 3rd and 4th generation cephalosporins (ceftazidime and cefepime respectfully), and carbapenems like imipenem or meropenem.
Isolates demonstrated variable resistance to chloramphenicol, gentamicin, enrofloxacin, erythromycin, and ticarcillin
Antimicrobial discs used were ampicillin (10), amoxycillin/clavulanic acid (10/20), piperacillin (100), piperacillin/tazobactem (100), ticarcillin
/clavulanic acid (75/10), cefixime (5), cefuroxime (30), cefpodoxime (10), cephotaxime (30), ceftazidime (30), aztreonam (30), netilmycin (30), amikacin (30), gentamycin (30), chlorophenicol (30), co-trimoxazol (30), tetracycline (30), imipenam (10) and meropenam (10).
Products that combine a penicillin with a [beta]-lactamase inhibitor, such as clavulanate with amoxicillin (Augmentin) or ticarcillin
(Timentin) and sulbactam with ampicillin (Unasyn), also appear to be safe during pregnancy.
and erythromycin were added to the therapeutic regimen.