This artificial menopause can be partially compensated by adding the synthetic tibolone
, which relieves menopausal symptoms and does not stimulate fibroid development.
In particular, tibolone
administration, a tissue-specific compound with estrogenic, progestogenic, and weak androgenic activities , increased muscle cross-sectional area .
(39) Even synthetic steroid compounds such as tibolone
may improve sexual function, although it is not FDA approved for that purpose.
Some of these are menopausal hormone therapy, tibolone
, the use of selective estrogen receptors modulators such as tamoxifen and raloxifene, and bisphosphonates and RANKL inhibitors like denosumab.
was another agent but there is risk of stroke.
prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus," Neurochemical Research, vol.
is a synthetic steroid prodrug used to relieve menopausal symptoms and to reduce bone demineralization [2, 3].
Kloosterboer, "Effect of tibolone
and raloxifene on the tail temperature of oestrogen-deficient rats," European Journal of Pharmacology, vol.
A review published in 2015 found low to moderate quality evidence that add-back therapy with tibolone
, raloxifene, estriol, and ipriflavone helps to preserve bone density and that medroxyprogesterone acetate (MPA) and tibolone
may reduce vasomotor symptoms.
Among the patients, 18 took estrogen only and 13 took either estrogen with tibolone
The impact of tibolone
on the libido is very impressive (androgen metabolites), especially on mood, which we have also seen in our clinical practice.