tibolone


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tibolone

A synthetic sex hormone drug used to treat menopausal and post-menopausal symptoms and disorders and to reduce the tendency to osteoporosis. A brand name is Livial.
References in periodicals archive ?
Contract notice: Conclusion of a non-exclusive discount agreement pursuant to section 130a (8) sgb v on the active substance tibolone, Atc g03cx01, For the period 1.9.2019 - 31.8.2021
This artificial menopause can be partially compensated by adding the synthetic tibolone, which relieves menopausal symptoms and does not stimulate fibroid development.
In particular, tibolone administration, a tissue-specific compound with estrogenic, progestogenic, and weak androgenic activities [112], increased muscle cross-sectional area [113].
Some of these are menopausal hormone therapy, tibolone, the use of selective estrogen receptors modulators such as tamoxifen and raloxifene, and bisphosphonates and RANKL inhibitors like denosumab.
Tibolone was another agent but there is risk of stroke.
Guerra-Araiza, "Tibolone prevents oxidation and ameliorates cholinergic deficit induced by ozone exposure in the male rat hippocampus," Neurochemical Research, vol.
Tibolone is a synthetic steroid prodrug used to relieve menopausal symptoms and to reduce bone demineralization [2, 3].
Kloosterboer, "Effect of tibolone and raloxifene on the tail temperature of oestrogen-deficient rats," European Journal of Pharmacology, vol.
A review published in 2015 found low to moderate quality evidence that add-back therapy with tibolone, raloxifene, estriol, and ipriflavone helps to preserve bone density and that medroxyprogesterone acetate (MPA) and tibolone may reduce vasomotor symptoms.
Among the patients, 18 took estrogen only and 13 took either estrogen with tibolone or tibolone only.
The impact of tibolone on the libido is very impressive (androgen metabolites), especially on mood, which we have also seen in our clinical practice.