tibial muscular dystrophy, tardive
tibial muscular dystrophy, tardiveAn autosomal dominant, late-onset distal myopathy (OMIM:600334) characterised by muscle weakness and atrophy usually confined to the anterior compartment of the lower leg, especially the tibialis anterior muscle. Onset occurs at age 35–45 or later with ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum.
Defects of TTN, which encodes a critical protein in striated muscle, cause tardive tibial muscular dystrophy.
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