thyrotropin alfa

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 [thi´ro-tro″pin, thi-rot´rah-pin]
a hormone secreted by the anterior lobe of the pituitary gland that has an affinity for and specifically stimulates the thyroid gland. Called also thyroid-stimulating hormone.
thyrotropin alfa a recombinant form of human thyrotropin; it binds to thyrotropin receptors and stimulates the steps in thyroid hormone synthesis, including iodine uptake and synthesis and secretion of thyroglobulin; used as a diagnostic adjunct in serum thyroglobulin testing, with or without radioiodine scanning, in followup of patients with well-differentiated thyroid cancer, administered intramuscularly.
thyrotropin-releasing hormone stimulation test (thyrotropin-releasing hormone test) a thyroid function test that assesses release of thyrotropin by the pituitary gland; a bolus of thyrotropin-releasing hormone is administered and serum concentrations of thyrotropin are assessed at intervals; if serum levels do not increase within 30 to 40 minutes, the pituitary thyrotrophs are dysfunctional. Called also TRH test and TRH stimulation test.
References in periodicals archive ?
Ladenson is a consultant for Genzyme Corp., maker of the rTSH compound thyrotropin alfa.
Framework agreement with a single operator per lot for provision of Ranibizumab (DOE), treprostinil (DOE), Doxorubicin (DOE) hydrochloride (DOE) in pegylated liposomal formulation, Paliperidone (DOE), human fibrinogen (DOE), Ipilimumab (DOE), Dexketoprofen (DOE) parental, sulfur hexafluoride (DOE), Dexamethasone intravitreal (DOE), imiglucerase (DOE) and thyrotropin alfa (DOE).

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