The lateral part of the pars distalis: pars distalis (PaD), acidophilic cell (AC), basophilic cell (BC), chromophobe cell (CC), sinusoid (Sin), somatotroph cell (SC), thyrotroph
cell (TC), gonadotroph cell (GC), corticotroph cell (ACTHC).
Eighteen of 20 patients carried PROP1 mutations had gonadotroph and somatotroph deficiency at postpubertal age, while two patients had corticotroph, thyrotroph
, and somatotroph deficiency at pubertal age.
The zebrafish light sensitivity is related to light induction of per2 and cry1a genes via D box-binding factor TEF (Thyrotroph
Embryonic Factor) [39-41], a signaling pathway which has recently been receiving the researchers' attention [14, 19].
The largest changes were in a set of transcription factors strongly associated with day-night gene regulation in other animals, including cryptochromes, thyrotroph
embryonic factor, and D site-binding protein.
Drosophila Pdp1 encodes a transcription factor highly homologous to the proline- and acidic amino acid-rich (PAR) subfamily of mammalian bZIP transcription factors, albumin D site-binding protein (DBP), hepatic leukemia factor (HLF), and thyrotroph
embryonic factor (TEF).
The increased level of TSH may potentiate the risk of thyrotroph
hyperplasia and possible adenoma formation (29-32).
Invasion is characteristic of thyrotroph
adenomas, silent corticotroph adenomas, and the unusual plurihormonal silent subtype 3 adenomas.
This tight control depends on a negative feedback relationship at the level of the thyrotroph
between TSH and thyroid hormone, which is logarithmic.
Mutations of the PROP1 primarily affects thyrotroph
, lactotroph, gonadotroph, and somatotroph cells.
Impaired pituitary thyrotroph
function in uncontrolled type 2 diabetes mellitus normalization on recovery.
The diminished thyroid hormone feedback on the pituitary thyrotroph
leads to an increase in TSH secretion, stimulating the thyroid gland.