The largest changes were in a set of transcription factors strongly associated with day-night gene regulation in other animals, including cryptochromes, thyrotroph
embryonic factor, and D site-binding protein.
The increased level of TSH may potentiate the risk of thyrotroph
hyperplasia and possible adenoma formation (29-32).
Invasion is characteristic of thyrotroph
adenomas, silent corticotroph adenomas, and the unusual plurihormonal silent subtype 3 adenomas.
Somatotroph, lactotroph and thyrotroph
function in three-week-old gilts reared in a hot or cool environment.
Pituitary pseudotumor (pituitary thyrotroph
hyperplasia) caused by unrecognized and untreated hypothyroidism has been described as a rare condition, mostly in adults.
This tight control depends on a negative feedback relationship at the level of the thyrotroph
between TSH and thyroid hormone, which is logarithmic.
Impaired pituitary thyrotroph
function in uncontrolled type 2 diabetes mellitus normalization on recovery.
Thyroid stimulating hormone is a peptide hormone, composed of a distinct [beta]-subunit and a common [beta]-subunit that is secreted by the thyrotroph
cells of the anterior pituitary gland.
TSH below normal TSH above normal Primary hyperthyroidism Primary hypothyroidism Pituitary/hypothalamic disease Pituitary thyrotroph
adenoma with central hypothyroidism Pituitary resistance to thyroid hormone (central hyperthyroidism) Generalized thyroid hormone resistance Prolonged thyrotroph
cell Thyrotoxicosis from overly rapid suppression after recent correction of severe hypothyroidism hyperthyroidism in euthyroid with parenteral [T.
3], suggests altered pituitary thyrotroph
or hypothalamic responsiveness to circulating thyroid-hormone levels.
Ultrastructurally, well-differentiated adenomatous thyrotrophs
resemble normal ones, whereas poorly differentiated adenomas were composed of elongated angular cells with irregular nuclei, poorly developed rough endoplasmic reticulum, long cytoplasmic processes, and sparse small secretory granules (50–200 nm) that mostly line up along the cell membrane [Figure 2].
Pit-1 gene expression is essential for the growth of some regulatory processes in the body of animals such as the ability of normal survival, differentiation and development of the three cell types of adenohypophysis, namely somatotrophs, lactotrophs and thyrotrophs