i wsp.: Thyromimetic
actions of tetrabromobisphenol A (TBBPA) in steatotic FaO rat hepatoma cells.
Scientists have designed another potentially pharmacologically useful compound - GC-24 (4), a second-generation thyromimetic
molecule that differs from GC-1 (3) in the 3' position of the second aromatic ring, where a benzyl group substitutes the isopropyl group (Figure 2).
Recently completed studies from the Neurotoxicology Laboratory and Pharmaceutical Research Institute have demonstrated that neurotoxic thyromimetic
PCB induce angiogenesis through the [alpha]v[beta]3 integrin receptor.
TRIAC is able to inhibit the secretion and biological activity of TSH with very little thyromimetic
effects at the level of peripheral tissues (26-28).
Tiratricol (Triac), a substance that has weak thyromimetic
effects, resulted in a case of documented hyperthyroidism secondary to its use.
He also highlighted two other investigational thyromimetic compounds with potent lipid-lowering properties: eprotirome and MB07811.
Ladenson said two phase II studies of the synthetic thyromimetic agent have been completed.
That's because thyroid hormone receptor-beta, while present mainly in the liver, is also widely distributed elsewhere in the body, including the pituitary, raising the possibility of systemic side effects even with selective thyromimetic agonist therapy, according to Dr.
Ladenson said that two phase II investigations of the synthetic thyromimetic
agent have been completed.
Tumors and foci induced by peroxisome proliferators have been suggested to have a phenotype of increased mitochondrial proliferation and mitochondrial enzymes (thyromimetic
rather than insulinomimetic) (Keshava and Caldwell 2006).