FOXE1

(redirected from thyroid transcription factor 2)

FOXE1

An intronless gene on chromosome 9q22 that encodes a member of the forkhead family of transcription factors, specifically a thyroid transcription factor, which plays a crucial role in thyroid morphogenesis.

Molecular pathology
FOXE1 mutations are linked to congenital hypothyroidism and cleft palate with thyroid dysgenesis.
References in periodicals archive ?
15, 70) Thyroid transcription factor 2 expression is restricted to the thyroid; anterior pituitary; epithelia of the oropharynx, trachea, and esophagus; exocrine cells of the seminiferous tubules of the testis; and epidermis and hair follicles.
Sequeira M, Al-Khafaji F, Park S, et al: Production and application of polyclonal antibody to human thyroid transcription factor 2 reveals thyroid transcription factor 2 protein expression in adult thyroid and hair follicles and prepubertal testis.
In a minority of these patients, the congenital hypothyroidism is associated with mutations in genes responsible for the development or growth of thyroid follicular cells: thyroid transcription factor 1 (TTF-1; also known as TITF1, NKX2-1, or T/EBP) (3,4), thyroid transcription factor 2 (TTF-2; also known as TITF2, FOXE1, or FKHL15) (5), paired box transcription factor 8 (PAX-8) (6-9), thyrotropin [(TSH).