thyroid peroxidase


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thyroid peroxidase

thyroid oxidoreductase that catalyzes incorporation of iodide to tyrosine residues in the production of thyroxine, in a process termed organification (q.v.); deficiency of this enzyme leads to a loss of the iodotyrosine derivatives and iiodine from the thyroid and results in goiter.

thyroid peroxidase

thyroid oxidoreductase that catalyzes incorporation of iodide to tyrosine residues in the production of thyroxine, in a process termed organification (q.v.); deficiency of this enzyme leads to a loss of the iodotyrosine derivatives and iiodine from the thyroid and results in goiter.
References in periodicals archive ?
Identification of a mutation in the coding sequence of the human thyroid peroxidase gene causing congenital goiter.
Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent thyroid peroxidase. Iron deficiency anemia blunts and iron supplementation improves the efficacy of iodine supplementation.
Van Baar et al., "Maternal thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?" Journal of Clinical Endocrinology and Metabolism, vol.
For individuals with an increased TSH, 62% were positive for either thyroglobulin autoantibodies or thyroid peroxidase autoantibodies, and 23% were positive for both.
Once inside the thyroid epithelial cell, iodide is transported to the apical plasma membrane, and thyroid peroxidase, an integral membrane enzyme, catalyzes sequential reactions in thyroid hormone production.
The thyroid peroxidase antibodies (anti-TPO) measurement showed no significant difference between the breast cancer groups, fibrocystic group and the normal healthy control group (p > 0.05).
[13] showed that 3.7% of Spanish children and adolescents have positive thyroid antibodies (2.3% for thyroid peroxidase antibodies (TPO-Ab) and 3% for thyroglobulin antibodies (Tg-Ab)).
At the follow-up visit, patients reported medical history and current medication and were weighed to the nearest 0.5 kg wearing indoor clothes and without shoes, and a nonfasting venous blood sample was collected and analyzed for serum concentrations of TSH and antibodies against thyroid peroxidase (TPO-ab).
Parameters of thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and TSH receptor auto antibodies (TRAb) were investigated in the cases whose TSH, sT3 and sT4 levels were different than the reference values after examination of the endocrinologist.
Women who are known to be positive for autoantibodies to thyroid peroxidase (TPO-Ab) should have a TSH test performed at 3 and 6 months post partum.
An Italian study showed that euthyroid women who are positive for thyroid peroxidase antibody (TPO Ab) had a 22% rate of premature deliveries and a 14% rate of miscarriage, compared with rates of 8% and 2% among euthyroid women who are not positive for the antibodies.

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