Identification of a mutation in the coding sequence of the human
thyroid peroxidase gene causing congenital goiter.
Iron deficiency impairs thyroid hormone synthesis by reducing activity of heme-dependent
thyroid peroxidase. Iron deficiency anemia blunts and iron supplementation improves the efficacy of iodine supplementation.
Van Baar et al., "Maternal
thyroid peroxidase antibodies during pregnancy: a marker of impaired child development?" Journal of Clinical Endocrinology and Metabolism, vol.
For individuals with an increased TSH, 62% were positive for either thyroglobulin autoantibodies or
thyroid peroxidase autoantibodies, and 23% were positive for both.
Once inside the thyroid epithelial cell, iodide is transported to the apical plasma membrane, and
thyroid peroxidase, an integral membrane enzyme, catalyzes sequential reactions in thyroid hormone production.
The
thyroid peroxidase antibodies (anti-TPO) measurement showed no significant difference between the breast cancer groups, fibrocystic group and the normal healthy control group (p > 0.05).
[13] showed that 3.7% of Spanish children and adolescents have positive thyroid antibodies (2.3% for
thyroid peroxidase antibodies (TPO-Ab) and 3% for thyroglobulin antibodies (Tg-Ab)).
At the follow-up visit, patients reported medical history and current medication and were weighed to the nearest 0.5 kg wearing indoor clothes and without shoes, and a nonfasting venous blood sample was collected and analyzed for serum concentrations of TSH and antibodies against
thyroid peroxidase (TPO-ab).
Parameters of
thyroid peroxidase antibodies (TPOAb), thyroglobulin antibodies (TgAb) and TSH receptor auto antibodies (TRAb) were investigated in the cases whose TSH, sT3 and sT4 levels were different than the reference values after examination of the endocrinologist.
Women who are known to be positive for autoantibodies to
thyroid peroxidase (TPO-Ab) should have a TSH test performed at 3 and 6 months post partum.
Thyroid peroxidase and TG antibodies were measured by an agglutination method.
An Italian study showed that euthyroid women who are positive for
thyroid peroxidase antibody (TPO Ab) had a 22% rate of premature deliveries and a 14% rate of miscarriage, compared with rates of 8% and 2% among euthyroid women who are not positive for the antibodies.
