The company's clinical programs include VK2809, a novel, orally available, small molecule selective thyroid hormone receptor beta
agonist for the treatment of lipid and metabolic disorders, including non-alcoholic steatohepatitis (NASH).
Madrigal Pharmaceuticals has initiated its Phase 3 trial in NASH with its once daily, oral thyroid hormone receptor beta
selective agonist, MGL-3196, resmetirom.
Hypothyroidism condition increased expression of collagen precursor in rat CF culture, while TH treatment reversed this effect only in the presence of thyroid hormone receptor beta
and alpha (TR[beta] and TR[alpha]) .
Resistance to thyroid hormone in a Chinese Family with R429Q mutation in the thyroid hormone receptor beta
In the present paper we describe the cloning and characterization of two TR genes, thyroid hormone receptor alpha (TRa) and thyroid hormone receptor beta (TRb) from ovary mRNA of a ovoviviparous fish Sebastes schlegelii.
Characterization of a sea bream (sparus aurata) thyroid hormone receptor beta clone expressed during embryonic and larval development.
3D-QSAR and molecular docking studies of selective agonists for the thyroid hormone receptor beta
. J Mol Graph Model 27:95-104.
Roth Capital analyst Scott Henry maintained a Buy rating on Viking Therapeutics while raising his price target to $13 from $7.50 saying the data yesterday from Madrigal Pharmaceuticals (MDGL) appears to validate the class of Thyroid Hormone Receptor Beta
agonist compounds, noting that Viking's VK2809 is a similar agonist.
Thyroid hormone resistance without mutations in thyroid hormone receptor beta
. Med Sci Monit 2007;13:CS67-70
(b) Gene symbol (c) Gene name (c) 2 PPM [O.sub.3] J03933 Thrb thyroid hormone receptor beta
, c-erbA-[beta] U73174 Gsr glutathione reductase L08447 Cd3z T-cell receptor CD3 zeta subunit L46791 Ces3 liver carboxylase precursor 10 (carboxylesterase 3) J02650 Rpl19 60S ribosomal protein L19 X96394 Abcc1 multidrug resistance protein D29766 Bcar1 FAK substrate p130 U49062 Cd24 signal transducer CD24 D16554 Ubb polyubiquitin 5 PPM [O.sub.3] X17163 Jun c-jun AP1 M84203 Kcnc2 potassium channel protein (KshIII A) D10862 Id1 inhibitor of DNA binding 1 M81855 Abcb1 multidrug resistance protein 1 D14051 Nos2 inducible nitric oxide synthase U45965 Cxc12 Mip-2 chemokine ligand 2 M86389 Hspb1 heat shock 27 kDa protein 1 L29232 1jf1r IGF-1 receptor D16237 Cdc25b M-phase inducerphosphatase 2 Accession no.
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta
gene: Analysis of 15 families.