A, Infiltrating plasma cells and intervening fibrosis replacing thyroid follicles
with a background showing Hashimoto thyroiditis.
Caption: FIGURE 5: Tissue section showing areas of necrosis and adjacent thyroid follicles
suggestive of tuberculosis of thyroid gland.
Expression of thyroid-specific auto-antibodies against thyroidal antigens leads to infiltration of immune cells in thyroid follicles
. Destruction of thyroid follicles
by these immune cells is the main mechanism of pathogenesis in HT .
latirostris, where this amine was detected on the base of the follicular epithelium, the location of the parafollicular cells, as well as between the thyroid follicles
Tissue transgl- utaminase antibodies in individuals with celiac dise- ase bind to thyroid follicles
and extracellular matrix and may contribute to thyroid dysfunction.
(15-18) Interestingly, our patient did not have any history of thyroid disease in the past, but she was thyrotoxic due to destruction of thyroid follicles
resulting in release of thyroid hormones into the circulation.
Thyroidal sympathetic adrenergic nerve terminals were found as single terminals between, and sometimes around, thyroid follicles
. Interfollicular terminals were numerous in the thyroids of adult mice, sheep, and hamsters, but fewer in the thyroids of adult rats and dogs and even fewer in the porcine thyroid.
The cells of these structures may originate from the cells of paramesonephricus ducts, salivary glands, breast tissue, thyroid follicles
, squamous epithelium or mesothelium.
Other causes of thyrotoxicosis include excessive production of thyroid hormones from sources outside the thyroid gland and leakage of stored thyroid hormones from storage in the thyroid follicles
. Symptoms of thyrotoxicosis include anxiety, weakness, palpitation, heat intolerance, emotional lability, tremor, increased perspiration, and/or weight loss even with normal or increased appetite (see Table 1).
At these high intakes, uptake of iodine into the thyroid gland appears to be inhibited, resulting in reduced synthesis of thyroxine and elevated secretion of TSH, which stimulates the thyroid follicles
to enlarge and multiply, producing a goitre.
Serial sectioning of thyroid follicles
showed thyroid hyperplasia with increased follicular epithelial cell height and reduced colloid in all groups of fish that had been exposed to perchlorate for 28 days, compared with control fish.