thyroglobulin

thyroglobulin

 [thi´ro-glob″u-lin]

an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the thyroid gland; its iodinated tyrosine moieties form the active hormones thyroxine and triiodothyronine.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin), [MIM*188450]

1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s): iodoglobulin, thyroprotein (1)

2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.

thyroglobulin

/thy·ro·glob·u·lin/ (thi″ro-glob´u-lin) an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and triiodothyronine.

thyroglobulin

(thī′rō-glŏb′yə-lĭn)

n.

1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.

2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.

thyroglobulin

A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T₃–iodothyronine and T₄–thyroxine. See T₃, T₄, Thyroid gland.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin)

1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism.

2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare: bioregulator

thyroglobulin

A large protein molecule, the storage form and precursor of the thyroid gland hormones.

thyroglobulin

a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.

thyroglobulin

1. an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and tri-iodothyronine.

2. a substance obtained by fractionation of thyroid glands from the pig, administered orally as a thyroid supplement in the treatment of hypothyroidism.