thyroglobulin


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thyroglobulin

 [thi´ro-glob″u-lin]
an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the thyroid gland; its iodinated tyrosine moieties form the active hormones thyroxine and triiodothyronine.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin), [MIM*188450]
1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s): iodoglobulin, thyroprotein (1)
2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.

thyroglobulin

/thy·ro·glob·u·lin/ (thi″ro-glob´u-lin) an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and triiodothyronine.

thyroglobulin

(thī′rō-glŏb′yə-lĭn)
n.
1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.
2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.

thyroglobulin

A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T3–iodothyronine and T4–thyroxine. See T3, T4, Thyroid gland.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin)
1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism.
2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare: bioregulator

thyroglobulin

A large protein molecule, the storage form and precursor of the thyroid gland hormones.

thyroglobulin

a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.

thyroglobulin

iodine protein of thyroid gland

thyroglobulin

1. an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and tri-iodothyronine.
2. a substance obtained by fractionation of thyroid glands from the pig, administered orally as a thyroid supplement in the treatment of hypothyroidism.
References in periodicals archive ?
Respective roles of thyroglobulin, radioiodine imaging, and positron emission tomography in the assessment of thyroid cancer.
Preablation stimulated thyroglobulin is a good predictor of successful ablation in patients with differentiated thyroid cancer.
Serum thyroglobulin in the follow-up of patients with treated differentiated thyroid cancer.
Serum thyroglobulin levels at the time of 131I remnant ablation just after thyroidectomy are useful for early prediction of clinical recurrence in low-risk patients with differentiated thyroid carcinoma.
Clinical implication of F-18 FDG PET-CT for differentiated thyroid cancer in patients with negative diagnostic iodine-123 scan and elevated thyroglobulin.
Tolerance to thyroglobulin by activating suppressor mechanisms.
Thyroglobulin is exclusively produced in the thyroid follicular cells and undetectable serum thyroglobulin in our patient's aspirate also supported non-thyroidal nature of the nodule biopsied.
This finding together with the expression of sortilin 1 in ovarian carcinoma may explain the 4% incidence of metastasis of ovarian carcinoma to thyroid glands, rich in thyroglobulin (11) as well as the same incidence in brain metastases (12).
Building the thyroxine molecule needs three components--iodine, thyroglobulin and thyroperoxidase.
Antibodies against TPO and thyroglobulin are found in approximately 10% of the general population and in up to 25% of people with type 1 diabetes, said Dr.