thyroglobulin


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thyroglobulin

 [thi´ro-glob″u-lin]
an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the thyroid gland; its iodinated tyrosine moieties form the active hormones thyroxine and triiodothyronine.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin), [MIM*188450]
1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s): iodoglobulin, thyroprotein (1)
2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.

thyroglobulin

/thy·ro·glob·u·lin/ (thi″ro-glob´u-lin) an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and triiodothyronine.

thyroglobulin

(thī′rō-glŏb′yə-lĭn)
n.
1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.
2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.

thyroglobulin

A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T3–iodothyronine and T4–thyroxine. See T3, T4, Thyroid gland.

thy·ro·glob·u·lin

(thī'rō-glob'yū-lin)
1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism.
2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare: bioregulator

thyroglobulin

A large protein molecule, the storage form and precursor of the thyroid gland hormones.

thyroglobulin

a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.

thyroglobulin

iodine protein of thyroid gland

thyroglobulin

1. an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and tri-iodothyronine.
2. a substance obtained by fractionation of thyroid glands from the pig, administered orally as a thyroid supplement in the treatment of hypothyroidism.
References in periodicals archive ?
Utility of thyroglobulin measurement in fine-needle aspiration biopsy specimens of lymph nodes in the diagnosis of recurrent thyroid carcinoma.
Reproducibility of whole-body 131I scan and serum thyrotrop n and stimulated thyroglobulin values in patients studied twice after injection of recombinant human thyrotropin.
With extensive use in a modified incarnation, as the Beckman Access automated thyroglobulin immunoassay, these initial observation have been corroborated; the assay appears to have lesser rates and magnitude of interference compared with many others, but it is by no means free of these problems (15,31,32).
The present results are also consistent with limited animal studies reporting that rats fed DEHP through the diet displayed histopathologic alterations in the thyroid indicative of hyperactivity, increased thyroglobulin turnover, and significantly decreased plasma [T.
All of the patients had their thyroglobulin measured with the ultrasensitive chemoluminescent assay before and after receiving recombinant TSH.
Furthermore, the combination of immunohistochemistry staining with thyroglobulin, TTF-1, inhibin, WT1 (Wilms tumor 1), and CA 125 will help differentiate these ovarian primary tumors from thyroid-type carcinoma.
Clinical impact of (18)F-FDG PET in thyroid carcinoma patients with elevated thyroglobulin levels and negative (131)I scanning results after therapy.
positive results for thyroglobulin and thyroid transcription factor-1; a distinctive cell-membrane staining pattern for MIB-1; negative results for calcitonin and HBME-1; and either positive or negative results for cytokeratin 19, which is strongly and diffusely positive in papillary carcinoma (2, 3).
Early adaptation of thyrotropin and thyroglobulin secretion to experimentally decreased iodide supply in man.
Immunohistochemistry showed a strong expression of thyroglobulin in the papillary component and weaker patchy expression in the poorly differentiated area.
TSH, antibodies to thyroperoxidase and thyroglobulin, and the prevalence of goiter as identified on ultrasound examination in 50 women with breast cancer and 30 age-matched healthy controls.