thyroglobulin
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thyroglobulin
[thi´ro-glob″u-lin]an iodine-containing glycoprotein of high molecular weight found in the colloid of the follicles of the thyroid gland; its iodinated tyrosine moieties form the active hormones thyroxine and triiodothyronine.
thy·ro·glob·u·lin
(thī'rō-glob'yū-lin), [MIM*188450]1. A protein that contains precursors of thyroid hormone usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein and the combination of two iodotyrosines to form thyroxine, the fully iodinated thyronine; secretion of thyroid hormone requires proteolytic degradation of thyroglobulin, with the attendant release of free hormone; a defect in thyroglobulin metabolism will lead to hypothyroidism. Synonym(s): iodoglobulin, thyroprotein (1)
2. A substance obtained by the fractionation of thyroid glands from the hog, Sus scrofa, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
thyroglobulin
/thy·ro·glob·u·lin/ (thi″ro-glob´u-lin) an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and triiodothyronine.thyroglobulin
(thī′rō-glŏb′yə-lĭn)n.
1. A thyroid protein that is the precursor to iodine-containing hormones and is typically present in the colloid of thyroid gland follicles.
2. A substance extracted from the thyroid glands of hogs, formerly used as a thyroid hormone supplement to treat hypothyroidism.
thyroglobulin
A 669 kD iodine-rich glycoprotein secreted by thyroid follicular cells into thyroid colloid where it is iodinated; once resorbed by follicular cells, it is cleaved into multiple units of T3–iodothyronine and T4–thyroxine. See T3, T4, Thyroid gland.thy·ro·glob·u·lin
(thī'rō-glob'yū-lin)1. A protein that contains thyroid hormone, usually stored in the colloid within the thyroid follicles; biosynthesis of thyroid hormone entails iodination of the l-tyrosyl moieties of this protein. A defect in thyroglobulin will lead to hypothyroidism.
2. A substance obtained by the fractionation of thyroid glands from pigs, Sus scrofula, containing not less than 0.7% of total iodine; used as a thyroid hormone in the treatment of hypothyroidism.
Compare: bioregulator
Compare: bioregulator
thyroglobulin
A large protein molecule, the storage form and precursor of the thyroid gland hormones.thyroglobulin
a protein that contains and stores THYROXINE and triiodo-thyroxine in the THYROID GLAND.thyroglobulin
iodine protein of thyroid glandthyroglobulin
1. an iodine-containing glycoprotein of high molecular weight, occurring in the colloid of the follicles of the thyroid gland; the iodinated tyrosine moieties of thyroglobulin form the active hormones thyroxine and tri-iodothyronine.
2. a substance obtained by fractionation of thyroid glands from the pig, administered orally as a thyroid supplement in the treatment of hypothyroidism.