A mild deficiency of zinc is associated with decreased thymulin
activity, reduced ratio of CD4+/CD8+ t-cells, and decreased production of interleukin-2.
, a thymus specific hormone, which is required for the maturation of T-helper cells, requires zinc for activity.
(facteur thymique serique) and zinc contents of the thymus glands of malnourished children.
The thymus produces several putative thymic hormones: thymosin alpha 1, thymulin
, and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T cells in the periphery, thus maintaining their commitment to the T cell system.
was determined by enzyme-linked immunosorbent assay (ELISA) (PromoKine, PromoCell Gmbh, Germany) according to the manufacturer's recommendations.
Effect of occupational exposure to elemental mercury in the amalgam on thymulin
hormone production among dental staff.
In a murine model Wirth et al (13) have reported that short periods of zinc deficiency resulted in rapid atrophy of the thymus, with preferential involution of the cortex, reduced production of thymulin
, along with substantial reductions in the total numbers of lymphocytes and phagocytes.
Birds provided diets supplemented with a more available zinc source (ZnMet) might have induced thymulin
activity, and therefore promoted immune responses through increased maturation of T-lymphocytes and activation of Blymphocytes by T-helper cells.