thymopoietin


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thymopoietin

 [thi″mo-poi´ĕ-tin]
a polypeptide hormone secreted by the thymus; it induces the proliferation of lymphocyte precursors and their differentiation into T-lymphocytes.

thy·mo·poi·et·in

(thī'mō-poy-ē'tin), [MIM*188380]
Formerly called thymin; a polypeptide hormone that induces differentiation of lymphocytes to thymocytes.
See also: thymic lymphopoietic factor.

TMPO

A gene on chromosome 12q22 that encodes thymopoietin, which may help direct nuclear lamina assembly and maintain the nuclear envelope’s structural organisation. Thymopoietin may act as a receptor for attachment of lamin filaments to the inner nuclear membrane.

Molecular pathology
Defects in TMPO cause cardiomyopathy dilated type 1.
References in periodicals archive ?
Thymus not only serves as the location of T lymphocytes formation, but also secretes hormones, including thymopoietin and thymosin [38].
mimic the activity of the youth hormone thymopoietin ...
A new peptide has been developed that mimics the action of the body's own natural youth hormone, thymopoietin. As a result, it helps trigger cellular reactions and reparative processes that are usually only seen in much younger skin.
By mimicking thymopoietin, this anti-aging peptide known as Acetyl Tetrapeptide-2 helps rejuvenate facial skin by improving skin tone and texture.
Thymopoietin is a polypeptide hormone secreted by the thymus that affects the rate at which your skin ages.
(4) Simply put, thymopoietin affects the body's capacity to maintain youthful function in everything from skin cells to brain cells.
All of these biological processes that are vital for the health and longevity of your skin are largely controlled by thymopoietin and the thymus.
Humans express diminished thymus and spleen size, the smaller number of lymphocyte counts, reduced cell-mediated immunity and thymopoietin production (Ferguson et al., 1974; Chandra, 1975; Manerikar et al., 1976; Mussi-Pinhata et al., 1993; Neumann et al.,1998; McDade et al., 2001).
The human thymus produces at least seven thymic proteins: thymopoietin, thymosin alpha, thymulin, thymic humoral factor, hormonal thymic factor, serum thymic factor, and other thymic factors.
The thymus produces several putative thymic hormones: thymosin alpha 1, thymulin, and thymopoietin, which have been reported to circulate and to act on both prothymocytes and mature T cells in the periphery, thus maintaining their commitment to the T cell system.
A large number of distinct factors are necessary to maintain a balanced production between the various types of T lymphocytes; these factors include almost all interleukins, thymosins, thymopoietin, thymic humoral factor, thymic factor X, serum thymic factor, amongst others.