Biopharmaceutical company Modis Therapeutics revealed on Tuesday the receipt of European Medicines Agency (EMA) PRIME (PRIority MEdicines) designation for its investigational MT1621 for patients with
thymidine kinase 2 deficiency (TK2d).
The liver regeneration parameters (
thymidine kinase, regeneration rate, mitotic index) and antioxidant enzyme levels (glutathione reductase, myeloperoxidase, MDA levels) were showed to be significant differences among the sham, control, FK506 and EGb761 + FK506 groups (p<0.05).
The cytosolic activity of
thymidine kinase (TK) was assayed according to Sauer and Wilmanns [28]; briefly: cytosolic samples were incubated with a reaction mixture consisting in 0.2 mol/L Tris-HCl pH 8.0,10 mmol/L EDTA, 20 mmol/L Mg[Cl.sub.2], 40 mmol/L ATP, 450 [micro]mol/L thymidine, and 4.5 [micro]Ci [[sup.3]H]-Thymidine for one hour at 37[degrees]C.
In 2007, a separate group of workers individually cloned and expressed BTV proteins into the
thymidine kinase gene of the Kenya Sheep (KS-1) vaccine strain of capripoxvirus.
Biovica has acquired cSens AB, a company that has developed a PCR-based platform for the analysis of serum
thymidine kinase (TK) enzyme activity, which correspond to tumor proliferation and cancer aggressiveness.
HSV-1 codes for its own
thymidine kinase allowing it to replicate in both dividing and non-dividing cells, however dlsptk is tk-null.
Nucleotide sequences of the hemagglutinin,
thymidine kinase, and A-type inclusion body protein genes were identical to those of CPXV strains T2000 and E1989 previously identified in Finland (3).
More recently, a gE and
thymidine kinase double deletion BoHV-5 recombinant strain was constructed and proposed as a candidate vaccine strain (14).
Patients received injections of an adenoviral vector containing a herpes simplex
thymidine kinase gene with no systemic immune response.
It preferentially hit tumor cells because the researchers had engineered the virus to lack an enzyme called
thymidine kinase, which it needs.
Their antiviral effect is dependent on the phosphorylation of viral
thymidine kinase.
In addition, the serum concentrations of
thymidine kinase, [[beta].sub.2] microglobulin, and soluble CD23 have also been reported to help improve prognostication in CLL (5).
