thromboxanes


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Related to thromboxanes: Eicosanoids, Leukotrienes

throm·box·anes

(throm-boks'ānz),
A group of compounds, included in the eicosanoids, formally based on thromboxane, but with the terminal COOH group present; biochemically related to the prostaglandins and formed from them through a series of steps involving the formation of an endoperoxide (an O-O bridge between carbons 9 and 11 in the prostaglandins) by a cyclooxygenase, followed by a rearrangement (catalyzed by thromboxane synthase) that inserts one of the two oxygen atoms between carbons 11 and 12, leaving the other still bridging carbons 9 and 11. Thromboxanes are so named from their influence on platelet aggregation and the formation of the oxygen-containing six-membered ring (pyran or oxane). Like the prostaglandins, individual thromboxanes (abbreviated TX) are designated by letters (A, B, C, etc.) and subscripts indicating structural features.

throm·box·anes

(throm-bok'sānz)
A group of compounds, included in the eicosanoids, formally based on thromboxane, but with the terminal COOH group present; biochemically related to the prostaglandins and formed from them. Thromboxanes are so named from their influence on platelet aggregation and the formation of the oxygen-containing six-membered ring (pyran or oxane). Like the prostaglandins, individual thromboxanes (abbreviated TX) are designated by letters (A, B, C, and onward) and subscripts indicating structural features.

thromboxanes

Substances similar to the prostaglandins that promote blood clotting. Aspirin in small doses reduces the production of thromboxane by PLATELETS.
References in periodicals archive ?
The thiazolidinediones have been shown through the platelet PPAR gamma receptor to blunt the release of thromboxanes and CD40 ligand (37).
Picotamide, a combined inhibitor of thromboxane [A.
Licofelone also inhibits both cydooxygenase (COX)-1 and COX-2, the enzymes that convert arachidonic acid into prostaglandins and thromboxanes, which means that the drug is a dual LOX-COX inhibitor.
Thromboxane mediates diapedesis after ischemia by activation of neutrophil adhesion receptors interacting with basally expressed intercellular adhesion molecule-1.
The fractions containing prostaglandins and thromboxanes were resolved on TLC.
Bennett says they apparently reduce thromboxane synthesis and the clumping of blood-clotting cells called platelets.
Platelet activation is measurable by quantifying thromboxanes, platelet factor 4, and thrombomodulin (TM).
2]-antiplasmin, and t-PA/PAI complexes Platelets Thromboxanes, platelet factor 4, TM, and soluble P-selectin Vascular injury/distress PAI-1, S-TM, adhesion molecules, and P,E,L-selectins Table 2.
Each section incorporates a reasonable amount of detail and in parts, uses terminology that is perhaps more suited to the level of understanding expected of an undergraduate student with phrases such as, "prostaglandins and thromboxanes are lipid derived powerful and important mediators of inflammatory reactions," (Shankman & Manske, 2011, p.
COX pathway is responsible for transforming arachidonic acid to prostaglandins, prostacyclins and thromboxanes.
Eicosanoids, which include prostaglandins, thromboxanes, and leukotrienes, are compounds produced from dietary fat, primarily arachidonic acid.
The F2-isoprostane, 8-epiprostaglandin-F2-[alpha], a potent agonist of the vascular thromboxane endoperoxide receptor, is a platelet thromboxane endoperoxide receptor antagonist.