thromboxane


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thromboxane

 [throm-bok´sān]
an intermediate in the metabolic pathway of arachidonic acid, formed from prostaglandin endoperoxides, and released from suitably stimulated platelets; the unstable form, thromboxane A2, is a potent inducer of platelet aggregation and constrictor of arterial smooth muscle.

throm·box·ane

(throm-bok'sān),
The formal parent of the thromboxanes; prostanoic acid in which the -COOH has been reduced to -CH3 and an oxygen atom has been inserted between carbons 11 and 12.

thromboxane

(thrŏm-bŏk′sān)
n.
Any of several compounds, originally derived from prostaglandin precursors in platelets, that stimulate aggregation of platelets and constriction of blood vessels.
References in periodicals archive ?
(1984) Prostacyclin and thromboxane synthase as P450 enzymes.
Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling.
Arendshorst, "Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice," Journal of the American Society of Nephrology, vol.
Seki, "An imbalance between prostacyclin and thromboxane in relation to cerebral blood flow in neonates with maternal preeclampsia," Prostaglandins & Other Lipid Mediators, vol.
Vollaard, A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers, British Journal of Clinical Pharmacology, 53(6), 644-647 (2002).
Several studies in different populations have shown protective mechanisms for risk with the association of low doses of calcium plus linoleic acid by improving the balance between thromboxane A2/prostaglandin E2, by reducing intracellular free calcium, by antagonizing the activity of the renin-angiotensin-aldosterone, by reducing the endothelial dysfunction, and by reversing the metabolic syndrome (5,6); which has not been observed with calcium supplementation alone (8).
The product is an active thromboxane receptor antagonist, to treat aspirin-exacerbated respiratory disease.
Thromboxane synthase (TXS) is an enzyme which catalyzes prostaglandin endoperoxide into thromboxanes.
"Even a single meal high in fat and cholesterol may cause the body to release a hormone, thromboxane, which causes the arteries to constrict and the blood to clot fasterone reason heart patients often get chest pains after eating a fatty meal," Ornish said.
Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane A2.
Compared to smaller platelets, larger platelets have more granules, aggregate more rapidly with collagen, have higher thromboxane A2 level, and express more glycoprotein Ib and IIb/IIIa receptors.