(1984) Prostacyclin and thromboxane
synthase as P450 enzymes.
Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane
formation and Ca2+ signaling.
receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice," Journal of the American Society of Nephrology, vol.
Seki, "An imbalance between prostacyclin and thromboxane
in relation to cerebral blood flow in neonates with maternal preeclampsia," Prostaglandins & Other Lipid Mediators, vol.
Vollaard, A comparison of the effects of nabumetone vs meloxicam on serum thromboxane
B2 and platelet function in healthy volunteers, British Journal of Clinical Pharmacology, 53(6), 644-647 (2002).
Several studies in different populations have shown protective mechanisms for risk with the association of low doses of calcium plus linoleic acid by improving the balance between thromboxane
A2/prostaglandin E2, by reducing intracellular free calcium, by antagonizing the activity of the renin-angiotensin-aldosterone, by reducing the endothelial dysfunction, and by reversing the metabolic syndrome (5,6); which has not been observed with calcium supplementation alone (8).
The product is an active thromboxane
receptor antagonist, to treat aspirin-exacerbated respiratory disease.
synthase (TXS) is an enzyme which catalyzes prostaglandin endoperoxide into thromboxanes
"Even a single meal high in fat and cholesterol may cause the body to release a hormone, thromboxane
, which causes the arteries to constrict and the blood to clot fasterone reason heart patients often get chest pains after eating a fatty meal," Ornish said.
Aspirin plays a crucial physiological and pathophysiological role in cardiovascular diseases and cerebrovascular diseases by irreversibly inhibiting thromboxane
Compared to smaller platelets, larger platelets have more granules, aggregate more rapidly with collagen, have higher thromboxane
A2 level, and express more glycoprotein Ib and IIb/IIIa receptors.