thrombospondin


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Related to thrombospondin: endostatin, Vitronectin, Thrombospondin receptor

thrombospondin

(throm″bō-spon′dĭn),

TSP

A glycoprotein that prevents cell-to-cell adhesion and angiogenesis. Thrombospondin is secreted by some parasites and may enhance their ability to cause disease. It is also found in malignant tumors, where it may block tumor growth and metastasis.
References in periodicals archive ?
Only four positive thrombospondin expression findings in our research could be explained by several mechanisms.
Bornstein, "Thrombospondin: Synthesis and secretion by cells in culture," The Journal of Cell Biology, vol.
Expression of A disintegrin and metallopeptidase with thrombospondin motifs type 8 (ADAMTS8) in various chicken tissues.
Thrombospondin type 1 domain-containing 7A (THSD7A) was identified by Western-blotting and subsequent mass spectrometry and has a molecular size of approximately 250 kDa.
Oppositely, macrophage elastase produced by tumor-associated macrophages cleaves plasminogen, thrombospondin, and type XVIII collagen generating anti-angiogenic molecules, such as angiostatin, thrombospondin fragments, and endostatin, respectively.
(11-16) Interestingly, an abnormal stromal-epithelial interaction, with increased expression of messenger RNA for vascular endothelial growth factor, fibronectin, thrombospondin 1, and other factors involved in the formation of vascular stroma, and analogous to that noted in wound healing responses, has been reported in radial scars.
(2,3) Matrix metalloproteinases and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) play role in cartilage breakdown.
Chesterman, "Thrombospondin 1 is a tight-binding competitive inhibitor of neutrophil cathepsin G.
A more likely ligand would be a member of the thrombospondin gene family, as these extracellular matrix molecules are expressed in N.
Patients with type II diabetes have increased populations of platelets that express activation-dependent adhesion molecules, such as activated GpIIb-IIIa, lysosomal Gp53, thrombospondin, and Pselectin.
In supernatants collected from HUVECs cultured alone for 5 days, we measured detectable release of angiogenin (2157 pg/mL), PDGF-AA (1292 pg/mL), PDGFBB (1500 pg/mL), endostatin (5523 pg/mL), thrombospondin (169 pg/mL), PIGF (149 pg/mL) and VEGF-D (143 pg/mL), CXCL8 (368 pg/mL), MMP-2 (116ng/mL), sVEGFR-1 (>200,000 pg/mL), and sVEGFR-2 (152 pg/mL), while HUVEC did not produce HGF or CXCL10, and detectable release of these latter two cytokines were not induced by addition of VPA or ATRA.
Work from our lab has shown that TGF[beta]1 is increased in glaucomatous LC cells in comparison to normal LC cells [49] and treatment of normal LC cells with exogenous TGF[beta]1 upregulated profibrotic genes such as CTGF, collagen I, and thrombospondin [99].