thrombospondin


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Related to thrombospondin: endostatin, Vitronectin, Thrombospondin receptor

thrombospondin

/throm·bo·spon·din/ (throm″bo-spon´din) a glycoprotein that interacts with a wide variety of molecules, including heparin, fibrin, fibrinogen, platelet cell membrane receptors, collagen, and fibronectin, and plays a role in platelet aggregation, tumor metastasis, adhesion of Plasmodium falciparum, vascular smooth muscle growth, and tissue repair in skeletal muscle following crush injury.

thrombospondin

(throm″bō-spon′dĭn),

TSP

A glycoprotein that prevents cell-to-cell adhesion and angiogenesis. Thrombospondin is secreted by some parasites and may enhance their ability to cause disease. It is also found in malignant tumors, where it may block tumor growth and metastasis.

thrombospondin

an osteoblast product which binds to connective tissues and serum proteins and binds calcium to hydroxyapatite and to osteonectin.
References in periodicals archive ?
Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.
Thus, genomic studies on marbling have been performed to discover marbling-specific genes including ribosomal protein L27a (RPL27A), sphingosine-1-phosphate receptor 1 (S1PR1), ADAM metallopeptidase with thrombospondin type 1 motif 4 (ADAMTS4), hormone-sensitive lipase (LIPE), peroxisome proliferator-activated receptor alpha (PPAR), CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA), runt-related transcription factor 1 (RUNX1), and insulin (INS) in animal breeding researches (Lee et al.
b) Thrombospondin was markedly increased between T = 30 min and later time points in addition to the generation of proteolytic fragments observed in T = 48h samples.
05 compared to untreated JIA patients; WBC, white blood cell; RBC, red blood cell; Hb, hemoglobin; Ht, hematocrit; PLT, platelet; CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; ANA, antinuclear antibodies; RF, rheumatoid factor; MMP, matrix metalloproteinase; ADAMTS, a disintegrin and metalloprotease with thrombospondin motifs; TGF-[beta], transforming growth factor-beta; PDGF-BB, platelet derived growth factor-BB; * results reported in [7]; # results reported in [9].
Hogg, "Catalysis of disulfide isomerization in thrombospondin 1 by protein disulfide isomerase," Biochemistry, vol.
A disintegrin-like and metalloproteinase with thrombospondin motifs 12 has been first reported by Cal et al.
Patients with type II diabetes have increased populations of platelets that express activation-dependent adhesion molecules, such as activated GpIIb-IIIa, lysosomal Gp53, thrombospondin, and Pselectin.
In the last decade it has been recognized that TTP is due to a deficiency of von Willebrand factor (VWF) cleaving protease, ADAMTS13, (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) resulting in ultra-large multimers of VWF (ULVWF).
This facilitates binding of aIIbb3 to fibrinogen, fibrin, von Willebrand Factor (vWF)and fibronectin vitronectin and thrombospondin and promotes platelet aggregation.
Recent studies have indicated that the deficiency of A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif, 13 (ADAMTS13) is a cause of TTP.
differences in 2007 protein profiles between symbiotic & aposymbiotic larvae Corals A variety of Thrombospondin Schwarz et al.
Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS syn aptogenesis.