These new coated prosthetic heart valves will be designed for hemodynamic performance and durability similar to uncoated materials, combined with a greater thromboresistance
, both in vitro and in animal studies.
The changes in functional moieties within structure of a solid organic polymer can influence its dielectric properties, degradability, hydrophilicity, permeation, adhesion, dye absorption, thromboresistance
, and cellular attachment, which are important factors for engineering and biomedical applications .
The ATS Open Pivot AP360 Heart Valve allows for a number of design enhancements that lead to particularly outstanding performance in all areas considered important to valve selection: implantability, hemodynamics, thromboresistance
, durability and patient quality of life.
Pyrolytic carbon is mainly used as an artificial heart valve material because of its good strength, wear resistance and durability, and most importantly, thromboresistance
or the ability to resist blood clotting.
Dow Plastics announced a surface treatment technology that provides wettability, by reducing air bubble adhesion on plastic surfaces, and thromboresistance
, which inhibits blood clot formation.
These results indicate that the presence of hydrophilic PEO segments has much improved the thromboresistance
of segmented polyurethane and polyurethaneurea.
5 million grant from the National Institutes of Health (NIH) titled "Optimizing Cardiovascular Device Thromboresistance
for Eliminating Anticoagulants.
Genetically engineered endothelial cells have been seeded on fibronectin-coated vascular grafts to secrete increased amounts of tissue plasminogen activator enhancing thromboresistance
Howard Greisler and his associates at the Loyola Medical Center, Maywood, Illinois and published in the May issue of the Journal of Vascular Surgery under the title "Silyl-heparin bonding improves the patency and in vivo thromboresistance
of carbon-coated polytetrafluoroethylene vascular grafts.
The GORE PROPATEN Vascular Graft has previously demonstrated improved thromboresistance
and patency compared to standard ePTFE grafts in pre-clinical in vivo tests.
Van Nooten's interest in lower dose anticoagulation with the ATS prosthesis can be traced to early in vitro laboratory evaluations demonstrating unique flow characteristics in the ATS Open Pivot design that suggest increased thromboresistance
Integrated radial support offers all the benefits of a ringed graft, while the GORE PROPATEN Bioactive Surface helps to improve thromboresistance